DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20161919

Study of mild cognitive impairment by applying Kolkata cognitive screening battery in type 2 diabetes mellitus patients in India

Sangeeta Pednekar, Shilpa Karande, Madhura Parab, Dharmendra Pandey

Abstract


Background: Several prospective, large, population-based cohort studies have found that diabetes is associated with an increased risk of mild cognitive impairment (MCI). This study was aimed to determine the relationship between diabetes mellitus (DM) and MCI with respect to age of onset, duration, other co-morbidities, complications of diabetes and the effect of HbA1c on MCI, using Kolkata cognitive screening battery.

Methods: From 1st December 2014 to 31st May 2015 a unicentric, case control study was designed to include patients attending the medicine outpatient clinic of LTMGH as per the inclusion and exclusion criteria. The cognition was assessed by Kolkata cognitive screening battery and the scores were compared with control subjects to rule out cognitive decline. A score below 110 was taken as the cut-off for identifying the significantly impaired.

Results: 50 patients were included in study (mean age 57.02 years). The mean MCI score was 100.58 in the diabetic group, which was significantly less as compared to 123.35 as seen in the control group. Object naming test was the least affected. Furthermore, MCI had positive significant correlation (p<0.05) with nephropathy (p<0.05), retinopathy (p<0.05), HbA1c (p<0.05) and duration of DM (p<0.05). There was no significant co-relation between the sex of the patients and MCI (p>0.05).

Conclusions: There is a strong correlation of MCI with HbA1c. This implies that control of diabetes may help improve cognition and help in better management of diabetes as MCI disrupts the individual’s lifestyle and interferes with day-to-day activities. The results of our study warrant future research to improve our understanding regarding MCI and its correlation with diabetes.

 


Keywords


Aging, Cognitive function, Diabetes, Dementia, Risk factors

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References


Whitmer RA, Sidney S, Selby J, Johnston SC, Yaffe K. Midlife cardiovascular risk factors and risk of dementia in late life. Neurology. 2005;64(2):277-81.

Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol. 2006;5(1):64-74.

Ohara T, Doi Y, Ninomiya T, Hirakawa Y, Hata J, Iwaki T, et al. Glucose tolerance status and risk of dementia in the community: the Hisayama study. Neurology. 2011;77(12):1126-34.

India stats: Million plus cities in India as per Census 2011". Press Information Bureau, Mumbai (Press release). Press Information Bureau, Government of India. 31 October 2011.

Das SK, Banerjee TK, Mukherjee CS, Bose P, Biswas A, Hazra A, et al. An urban community-based study of cognitive function among non-demented elderly population in India. Neurol Asia. 2006;11:37-48.

Profenno LA, Porsteinsson AP, Faraone SV. Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders. Biol Psychiatry. 2010;67(6):505-12.

Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, et al. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci. USA. 2003;100(7):4162-7.

Yaffe K, Lindquist K, Schwartz AV, Vitartas C, Vittinghoff E, Satterfield S, et al. Advanced glycation end product level, diabetes, and accelerated cognitive aging. Neurology. 2011;77(14):1351-6.

Abbatecola AM, Rizzo MR, Barbieri M, Grella R, Arciello A, Laieta MT, et al. Postprandial plasma glucose excursions and cognitive functioning in aged type 2 diabetics. Neurology. 2006;67(2):235-40.

Launer LJ, Miller ME, Williamson JD, Lazar RM, Gerstein HC, Murray AM, et al. Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. Lancet Neurol. 2011;10(11):969-77.