DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20213072

A comparative study of collagen-based dressing versus conventional dressing in chronic ulcers

Shrashti Chaurasia, Arvind Diwaker, Nitin Garg

Abstract


Background: Collagen is a fibrous structure, proline-rich protein, comprised of three α-chains, plays an important role in each stage of wound healing, attracts fibroblasts and keratinocytes which in turn encourages debridement, angiogenesis and re-epithelialization

Methods: This is a prospective cohort study. After obtaining ethical clearance from Institute’s ethical committee, all the patients fulfilling inclusion criteria were enrolled and written consent was obtained from all the patients. Detailed history was enquired and recorded on a predesigned proforma. The ulcer healing, analysed as- Time required for appearance of healthy granulation tissue, 50% reduction in ulcer size, complete healing time, requirement of skin grafting, time required in return to daily activities.

Results: A significant decrease in time required for 50 % reduction in wound size with a mean difference of 18.5 in collagen group patients when compared to 37.5 and 33.0 in Normal saline group patients and Povidone iodine group patients. Chi square test was applied to assess the difference in proportions between groups t test was applied to compare the mean between the groups. P<0.05 was considered as statically significant.

Conclusions: Healing with collagen particles is early, compared to the conventional dressings with lesser requirement of skin grafting, number of dressings, shorter hospital stay. Dressing changed every 3-4 days. Healing occurs by formation of early granulation tissue and wound contraction.


Keywords


Dressing, Healthy granulation tissue, Skin grafting

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References


Kumar KS, Kartheek G. Comparative Study of Role of Collagen Preparations and Conventional Dressing in Different Types of External Ulcers. IJSS Journal of Surgery. 2018;4(1):5-11.

Sebastian KMS, Lobato I, Hernandez I. Efficacy and safety of autologous platelet rich plasma for the treatment of vascular ulcers in primary care: phase III study. BMC FamPract. 2014;15:211.

Greer N, Foman N, Dorrian J. Advanced wound care therapies for non-healing diabetic, venous, and arterial ulcers: a systematic review. 2012.

Martinez‐Zapata MJ, Martí‐Carvajal AJ, Sola I, Expósito JA, Bolibar I, Rodriguez L et al. Autologous platelet‐rich plasma for treating chronic wounds. Cochrane Database of Systematic Reviews. 2016;(5).

Fu X. Skin ulcers in lower extremities: the epidemiology and management in China. 2005;4(1):4-6.

Agale SV. Chronic leg ulcers: epidemiology, aetiopathogenesis, and management. Ulcers. 2013;2013.

Rayner R, Carville K, Keaton J, Prentice J, Santamaria N. Leg ulcers: atypical presentations and associated comorbidities. Wound Practice and Research. 2009;17(4):168-85.

Frykberg RG, Banks J. Challenges in the treatment of chronic wounds. Advances in wound care. 2015;4(9):560-82.

Shukla VK, Ansari MA, Gupta SK. Wound healing research: a perspective from India.2005;4(1):7-8.

Suresh DH, Suryanarayan S, Sarvajnamurthy S, Puvvadi S. Treatment of a non-healing diabetic foot ulcer with platelet-rich plasma. Journal of cutaneous and aesthetic surgery. 2014;7(4):229.

Nataraj C, Ritter G, Dumas S, Helfer FD, Brunelle J, Sander TW. Extracellular wound matrices: novel stabilization and sterilization method for collagen-based biologic wound dressings. Wounds: a compendium of clinical research and practice. 2007;19(6):148-56.

Park SN, Lee HJ, Lee KH, Suh H. Biological characterization of EDC-crosslinked collagen–hyaluronic acid matrix in dermal tissue restoration. Biomaterials. 2003;24(9):1631-41.

Nagata H, Ueki H, Moriguchi T. Fibronectin: Localization in normal human skin, granulation tissue, hypertrophic scar, mature scar, progressive systemic sclerotic skin, and other fibrosing dermatoses. Archives of dermatology. 1985;121(8):995-9.

Rahman G A, Adigun I A, Fadeyi A. Epidemiology, etiology, and treatment of chronic leg ulcer: Experience with sixty patients. Ann Afr Med. 2010;9:1-4.

Panda P, Tripathy S. Prevalence of microbial agents associated with chronic nonhealing ulcers: A cross-sectional study. Med J DY PatilVidyapeeth. 2020;13:447-53.

Sun X, Ni P, Wu M, Huang Y, Ye J, Xie T. A clinicoepidemiological profile of chronic wounds in wound healing department in Shanghai. The International Journal of Lower Extremity Wounds. 2017;16(1):36-44.

Jegoda RK. A comparative study of collagen granules vs conventional dressing in the management of chronic ulcer. IntSurg J. 2020;7:867-9.

Seth A, Attri AK, Kataria H, Kochhar S, Seth SA, Gautam N. Clinical Profile and Outcome in Patients of Diabetic Foot Infection. Int J Appl Basic Med Res. 2019;9(1):14-9.

Choudhary D, Insen SG, Goyal S. A comparative study of collagen dressings versus conventional dressings in wound healing in chronic ulcer. J. Evolution Med. Dent. Sci. 2017;6(5):361-3

Velappan DP, Gunasekaran S. A Comparative Study of Collagen Granule Vs Conventional Dressing in Case of Chronic Non-Healing Ulcers, International J Scient Res. 2017;6(4):339-42.

Singh O, Gupta SS, Soni M, Moses S, Shukla S, Mathur RK. Collagen dressing versus conventional dressings in burn and chronic wounds: a retrospective study. J Cutan Aesthet Surg.2011;4(1):12.