High incidences of low serum magnesium in pre-eclampsia and eclampsia than in normal pregnancy

Authors

  • Chaitali Mondal Department of Food and Nutrition, CMJ University, Meghalaya, India http://orcid.org/0000-0002-4133-8740
  • Dipak Das Department of Gynaecology, SDDM Hospital, Kolkata, West Bengal, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20214078

Keywords:

Eclampsia, Pre-eclampsia, Proteinuria, Serum magnesium

Abstract

Background: Hypertension is one of the most frequently encountered medical disorder in obstetrics practice and remain a major cause of maternal, fetal and neonatal morbidity and mortality. Objectives was to find out the high incidences of low serum magnesium in pre-eclampsia and eclampsia than in normal pregnancy.

Methods: All consenting 50 cases of normal pregnant women and 50 women with pre-eclampsia attending antenatal clinic for checkup of ≥20 weeks who fulfills the inclusion and exclusion criteria were included in the study. Serum magnesium was measured by Calmagite method.

Results: Out of 100 primigravidae 50 cases of pre-eclampsia women were in the age group of 18-30 years and the mean serum magnesium was 1.156±0.328. In contrast out of 50 cases of pregnant women were in the age group of 18-30 years and the mean serum magnesium was 1.907±0.321. The difference between the mean serum magnesium level in pre-eclampsia and normal pregnant women cases were statistically significant (p=0.0016). The study presented below it is clear that there are numerous factors that contribute to the causality of pre-eclampsia and from our analysis it was clear that the serum magnesium levels show an irregular pattern of fluctuations in cases suffering from pre-eclampsia and can be attributed to numerous physiological causes.

Conclusions: Our study shows a significant reduction of serum magnesium levels in pre-eclampsia cases compared to normal pregnant women and occurrence of both maternal and neonatal complications with the serum magnesium levels decreased.

Author Biography

Chaitali Mondal, Department of Food and Nutrition, CMJ University, Meghalaya, India

Department - Food and Nutrition

References

Mittal S, Shaikh MKS, Thakur R, Jain D. Comparison of serum calcium and magnesium levels between preeclamptic and normotensive healthy pregnant women. IJRCOG. 2014;3(4):959-62.

Sayyed KA, Sonttake AN. Electrolytes status in preeclampsia. IIRJ. 2013;3(3):30-6.

Kanagal DV. Levels of serum calcium and magnesium in preeclamptic and normal pregnancy: A study from Coastal India. J Clin Diagn Res. 2014;8(7):1-4.

Idogn ES, Imarengiaye CO, Momoh SM. Extracellular calcium and magnesium in preeclampsia and eclampsia. African J rep health. 2007;11(2):90-4.

Tavana Z, Hoseinmirzaei S. Comparison of maternal serum magnesium level in preeclampsia and normal pregnant women. Iran Red Cres Med J. 2013;15(12):1-4.

Pairu J, Triveni GS, Manohar A. The study of serum calcium and serum magnesium in pregnancy induced hypertension and normal pregnancy. Int J Reprod, Contracep Obstetr Gynecol. 2015;4(1):30-4.

Fawcett WJ, Haxby EJ, Male DA. Magnesium physiology and pharmacology. BJA. 1999;83(2):302-20.

Guhan VN. Serum calcium and magnesium levels in preeclamptic patients A case control study. Int J Pharm Sci Rev Res. 2014;26(1):149-51.

Ephraim RKD, Osakunor DNM, Denkyira SW, Eshun H, Amoah S, Anto EO. Serum calcium and magnesium levels in women presenting with pre-eclampsia and pregnancy-induced hypertension: a case-control study in the Cape Coast metropolis, Ghana. BMC Pregnancy and Childbirth. 2014;14(2):390.

Purohit A. Serum magnesium status in preeclampsia. Int J Med Sci Edu. 2016;3(1):1-6.

Sandip L, Bhushan M, Manohar M. Comparative study of serum calcium, magnesium and zinc levels in preeclampsia and normal pregnancy. Int J Rec Tre Sci Tech. 2014;9(3):422-6.

Cunningham FG. In Hypertensive disorders ch 40. Williams Obstetrics, 24Th edition, New York McGraw Hill Co. 2013;728-9.

WHO recommendations for prevention and treatment of preeclampsia and eclampsia. 2011. Available at: https://www.who.int/reproductivehealth/publications/maternal_perinatal_health/9789241548335/en/. Accessed on 2 July 2021.

Samar NE. Case control study of risk factors associated with preeclampsia in the Gaza Strip. J Med Med Sci. 2015;6(9):229-33.

Kirsten D, Deborah H. Risk factors for preeclampsia at antenatal booking: systematic review of controlled studies. Bri Med J. 2005;330(7491):565.

Downloads

Published

2021-10-28

How to Cite

Mondal, C., & Das, D. (2021). High incidences of low serum magnesium in pre-eclampsia and eclampsia than in normal pregnancy. International Journal of Research in Medical Sciences, 9(11), 3302–3308. https://doi.org/10.18203/2320-6012.ijrms20214078

Issue

Section

Original Research Articles