Published: 2021-10-28

High incidences of low serum magnesium in pre-eclampsia and eclampsia than in normal pregnancy

Chaitali Mondal, Dipak Das


Background: Hypertension is one of the most frequently encountered medical disorder in obstetrics practice and remain a major cause of maternal, fetal and neonatal morbidity and mortality. Objectives was to find out the high incidences of low serum magnesium in pre-eclampsia and eclampsia than in normal pregnancy.

Methods: All consenting 50 cases of normal pregnant women and 50 women with pre-eclampsia attending antenatal clinic for checkup of ≥20 weeks who fulfills the inclusion and exclusion criteria were included in the study. Serum magnesium was measured by Calmagite method.

Results: Out of 100 primigravidae 50 cases of pre-eclampsia women were in the age group of 18-30 years and the mean serum magnesium was 1.156±0.328. In contrast out of 50 cases of pregnant women were in the age group of 18-30 years and the mean serum magnesium was 1.907±0.321. The difference between the mean serum magnesium level in pre-eclampsia and normal pregnant women cases were statistically significant (p=0.0016). The study presented below it is clear that there are numerous factors that contribute to the causality of pre-eclampsia and from our analysis it was clear that the serum magnesium levels show an irregular pattern of fluctuations in cases suffering from pre-eclampsia and can be attributed to numerous physiological causes.

Conclusions: Our study shows a significant reduction of serum magnesium levels in pre-eclampsia cases compared to normal pregnant women and occurrence of both maternal and neonatal complications with the serum magnesium levels decreased.


Eclampsia, Pre-eclampsia, Proteinuria, Serum magnesium

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Mittal S, Shaikh MKS, Thakur R, Jain D. Comparison of serum calcium and magnesium levels between preeclamptic and normotensive healthy pregnant women. IJRCOG. 2014;3(4):959-62.

Sayyed KA, Sonttake AN. Electrolytes status in preeclampsia. IIRJ. 2013;3(3):30-6.

Kanagal DV. Levels of serum calcium and magnesium in preeclamptic and normal pregnancy: A study from Coastal India. J Clin Diagn Res. 2014;8(7):1-4.

Idogn ES, Imarengiaye CO, Momoh SM. Extracellular calcium and magnesium in preeclampsia and eclampsia. African J rep health. 2007;11(2):90-4.

Tavana Z, Hoseinmirzaei S. Comparison of maternal serum magnesium level in preeclampsia and normal pregnant women. Iran Red Cres Med J. 2013;15(12):1-4.

Pairu J, Triveni GS, Manohar A. The study of serum calcium and serum magnesium in pregnancy induced hypertension and normal pregnancy. Int J Reprod, Contracep Obstetr Gynecol. 2015;4(1):30-4.

Fawcett WJ, Haxby EJ, Male DA. Magnesium physiology and pharmacology. BJA. 1999;83(2):302-20.

Guhan VN. Serum calcium and magnesium levels in preeclamptic patients A case control study. Int J Pharm Sci Rev Res. 2014;26(1):149-51.

Ephraim RKD, Osakunor DNM, Denkyira SW, Eshun H, Amoah S, Anto EO. Serum calcium and magnesium levels in women presenting with pre-eclampsia and pregnancy-induced hypertension: a case-control study in the Cape Coast metropolis, Ghana. BMC Pregnancy and Childbirth. 2014;14(2):390.

Purohit A. Serum magnesium status in preeclampsia. Int J Med Sci Edu. 2016;3(1):1-6.

Sandip L, Bhushan M, Manohar M. Comparative study of serum calcium, magnesium and zinc levels in preeclampsia and normal pregnancy. Int J Rec Tre Sci Tech. 2014;9(3):422-6.

Cunningham FG. In Hypertensive disorders ch 40. Williams Obstetrics, 24Th edition, New York McGraw Hill Co. 2013;728-9.

WHO recommendations for prevention and treatment of preeclampsia and eclampsia. 2011. Available at: Accessed on 2 July 2021.

Samar NE. Case control study of risk factors associated with preeclampsia in the Gaza Strip. J Med Med Sci. 2015;6(9):229-33.

Kirsten D, Deborah H. Risk factors for preeclampsia at antenatal booking: systematic review of controlled studies. Bri Med J. 2005;330(7491):565.