Role of high sensitive c-reactive protein and serum uric acid in coronary artery diseases: a case control study


  • Nandini Takkalaki Department of Biochemistry, Al Ameen Medical College, Vijayapur, Karnataka, India
  • Raja Shekhar Muchchandi Department of Radiology, Al Ameen Medical College, Vijayapur, Karnataka, India
  • Krishnamurthy N. Department of Biochemistry, BGS, Bangalore, Karnataka, India



Coronary artery disease, Highly sensitive C - reactive protein, Serum uric acid


Background: Coronary artery diseases (CAD) are considered to be the major public health concerns throughout the world, including India. Despite significant improvement in the diagnosis, treatment and prevention, CAD remains the most common, acute, and chronic illness, which is the leading cause of mortality and morbidity in the world.

Methods: To estimate the serum uric acid and hs-CRP levels in coronary artery disease cases with diabetes mellitus and hypertension and compare with the healthy individuals.

Results: The mean serum uric acid levels were raised in cases (6.1±1.54 mg/dl) compared to the controls (5.16±1.007 mg/dl) which was significant statistically (p<0.008). The mean hs-CRP levels were raised in cases (7.1±8.122 mg/dl) compared to the controls (0.185±0.254 mg/dl) which was highly significant statistically.

Conclusions: Measurement of the levels of hs-CRP and serum uric acid in CAD might help in identifying the patient at increased risk of mortality.

Author Biography

Nandini Takkalaki, Department of Biochemistry, Al Ameen Medical College, Vijayapur, Karnataka, India

Department of Biochemistry

Al ameen medical college



Park K. In: Epidemiology of chronic non communicable diseases. Park’s Textbook of preventive and social medicine, 20th edition. Jabalpur: BHanotB. 2009;315-6.

Nagel T, Resnick N, Atkinson WJ, Dewey CF, Gimbrone MA. Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells. J Clin Invest. 1994;94:885-91.

Pepys MB, Baltz ML. Acute phase proteins with special reference to C-reactive protein and related proteins (pentraxins) and serum amyloid A protein. Adv Immunol. 1983;34:941-4.

Liuzzo G, Biasucci LM, Gallimore JR, Grillo RL, Rebuzzi AG, Pepys MB et al. The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. N Engl J Med. 1994;331:417-24.

Paul M. Ridker. Role of hs CRP in cardiovascular risk prediction. The American Journal of Managed Care. 2002;8:6-8.

Milions HJ, Kalantze KJ, Goudevenos JA, Seferiadis K, Mikhailidis DP, Elisaf MS. Serum uric acid levels and for acute ischemic non-embolic stroke in elderly subjects. J Intern Med. 2005;258:435-41.

Farmer JA, Torre G. Atherosclerosis and inflammation. Curr Atheroscler Rep. 2002;4:92-8.

Kenji T, Takahero S. Japan- Science link Japan. 2006;68:119-22.

Sharma SB, Garg S, Garg VA, Dwivedi S. hsCRP and oxidative stress in young CAD patients: A pilot study. Indian Journal of Clinical Biochemistry. 2008;23(4):334-6.

Soinio M, Mamiemi J, Laakso M, Lehto S, Rönnemaa T. High-sensitivity C-reactive protein and coronary heart disease mortality in patients with type 2 diabetes: a 7-year follow-up study. Diabetes Care. 2006;29:329-33.

De Beer FC, Hind CR, Fox KM. Measurement of serum C-reactive protein in myocardial ischemia and infarction. Br Heart J. 1982;47:239-43.

Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J, Watanabe S et al. Is There a Pathogenetic Role for Uric Acid in Hypertension and Cardiovascular and Renal Disease? Hypertension. 2003;41:1183-90.

Bickel C, Rupprecht HJ, Blankenberg S, Rippin G, Hafner G, Daunhauer A et al. Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease. Am J Cardiol. 2002;89:7-12.

Gryglewski RJ, Palmer RM, Moncada S. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature. 1986;320:454-6.

Freedman DS, Williamson DF, Gunter EW, Byers T. Relation of serum uric acid to mortality and ischemic heart disease. The NHANES I Epidemiologic Follow-up Study. Am J Epidemiol. 1995;141:637-64.

Fang J, Alderman MH. Serum uric acid and cardiovascular mortality: The NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey. JAMA. 2000;283(18):2404-10.

Hamidreza G, Maryam SA, Boroumand MA, Karimi A, Abbasi SH, Gholamreza D. Hyperuricemia and the Presence and Severity of Coronary Artery Disease. Lab Medicine. 2010;41:40-5.

Schlotte V, Sevanian A, Hochstein P, Weithmann KU. Effect of uric acid and chemical analogues on oxidation of human low density lipoprotein in vitro.Free Rad Biol Med. 1998;25:839-47.

Waring WS, Webb DJ, Maxwell SR. Uric acid as a risk factor for cardiovascular disease. Q J Med. 2000;93:707-13.

Leyva F, Anker SD, Godsland IF, Teixeira M, Hellewell PG, Kox WJ et al. Uric acid in chronic heart failure: a marker of chronic inflammation. Eur Heart J. 1998;19:1814-22.

Kang DH, Park SK, Lee IK, Johnson RJ. Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol. 2005;16:3553-62.




How to Cite

Takkalaki, N., Muchchandi, R. S., & N., K. (2021). Role of high sensitive c-reactive protein and serum uric acid in coronary artery diseases: a case control study. International Journal of Research in Medical Sciences, 9(8), 2414–2419.



Original Research Articles