Correlation of E23K gena KCNJ11 polymorphism as a Risk Factor for Obesity with Type 2 Diabetes Mellitus In Jayapura, Papua

Authors

  • Jems K. R. Maay Doctoral Program of Medicine, Faculty of Medicine Public Health and Nursing, University of Gadjah Mada, Yogyakarta, Indonesia http://orcid.org/0000-0001-7252-1014
  • Pramudji Hastuti Department of Biochemistry, Faculty of Medicine Public Health and Nursing, University of Gadjah Mada, Yogyakarta, Indonesia
  • Ahmad H. Sadewa Department of Biochemistry, Faculty of Medicine Public Health and Nursing, University of Gadjah Mada, Yogyakarta, Indonesia

DOI:

https://doi.org/10.18203/2320-6012.ijrms20212804

Keywords:

Obesity, Type 2 diabetes mellitus, Gene KCNJ11, Polymorphism

Abstract

Background: Pathophysiology of type 2 diabetes mellitus (T2DM) is influenced by the complex interaction of several genes that regulate energy metabolism in the body. Several polymorphisms that occur in many gene encode components of glucose metabolism regulation are significantly implicated in the onset of T2DM.

Methods: This case-control study. Case group with 58 subjects of T2DM patients with obesity and a control group with 58 subjects of non-DM obese patients from ethnic Papuans in Jayapura city, Indonesia.

Results: The results of the genotype frequency distribution (AA, GA, GG) and allele (A and G) showed statistically no significant differences. The relationship of anthropometry and blood chemical parameters with genotype (AA-GA-GG) gene potassium inwardly rectifying channel sub family J member 11 (KCNJ11) showed no statistically significant difference (p>0.05). The relationship of anthropometry and blood chemical parameters of genotype (AA-GA) gene KCNJ11 indicated that diastolic blood pressure variables, glucose, triglyceride, high density lipoprotein (HDL), insulin levels, homeostatic model assessment (HOMA) β, and insulin resistance (IR) had statistically significant differences.

Conclusions: There is no difference in frequency between genotypes and alleles of the gene KCNJ11 in the T2DM and non-DM group with obesity. There is a link between genotypes of the gene KCNJ11 and T2DM occurrence. As for the combined analysis between blood chemical parameters and genotypes of gene KCNJ11, there is a relationship between genotypes of the gene KCNJ11 and the incidence of T2DM in LDL variables, where the coefficient interval value increases in patients with T2DM.

Author Biographies

Jems K. R. Maay, Doctoral Program of Medicine, Faculty of Medicine Public Health and Nursing, University of Gadjah Mada, Yogyakarta, Indonesia

department of biochemistry

Pramudji Hastuti, Department of Biochemistry, Faculty of Medicine Public Health and Nursing, University of Gadjah Mada, Yogyakarta, Indonesia

Department of Biochemistry

Ahmad H. Sadewa, Department of Biochemistry, Faculty of Medicine Public Health and Nursing, University of Gadjah Mada, Yogyakarta, Indonesia

Department of Biochemistry

References

Suyono, S, Wapadji, S, Soegondo, S, Soewondo, P, Subekti, I. Integrated Diabetes Mellitus Management, Diabetes Mellitus Management Guide for Doctors and Educators. FKUI. Jakarta. 2009.

Koentjaningrat. Introduction to Anthropology. Vol I and II. 3rd edition. 2005.

Basic Health Research (Riskesdas). Health Research and Development Agency. Ministry of Health of the Republic of Indonesia. Jakarta. 2013.

Basic Health Research (Riskesdas). Health Research and Development Agency. Ministry of Health of the Republic of Indonesia, Jakarta. 2018.

World Health Organization. Diabetes. Fact sheet. 2011. Available at: https://www.who.int/news-room/fact-sheets/detail/diabetes. Accessed on 24 January 2021.

Riedel, MJ, Boora, P, Steckley, D, de Vries, G, Light, PE. Kir6.2 polymorphisms sensitize β-cell ATP sensitive Potassium channels to activation by Acyl CoAs: possible cellular mechanism for increased susceptibility to type 2 diabetes? Diabetes. 2003;52(10):2630-5.

Zhou, D, Zhang, D, Liu, Y, Zhao, T, Chen, Z, Liu, Z, et al. The E23K variation in the KCNJ11 gene is associated with type 2 diabetes in Chinese and East Asian populations. J Hum Genet. 2009;54(7):433-5.

Florez, JC. The genetic of type 2 diabetes: a realistic appraisal in 2008. J Clin endocrinol Metab. 2008;93:4633-42.

Schwanstecher, C, Meyer, U, Schwanstecher, M. Kir6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic β-cell ATP-sensitive K+ Channels. Diabetes. 2002;51(3):875-79.

Rastegari, A, Rabbani, M, Sadeghi, HM, Imani, EF, Hasanzadeh, A, Moazen, F. Association of KCNJ11 (E23K) gene polymorphism with susceptibility to type 2 diabetes in Iranian patients. Adv Biomed Res. 2015;6(4):1.

Perkeni. Consensus on the Management and Prevention of Type-2 Diabetes Mellitus in Indonesia, Executive Board of the Indonesian Association of Endocrinologists. 2006.

Dasmawati. Correlation of anthropometric measurements with blood pressure and plasma angiotensinogen in adults. Department of Nutrition Science Faculty of Medicine Andalas University. MKA. 2004;37:2.

Sunita, R, Sadewa, AH, Fatmawati, A. Lower HOMA-β Values are detected among individuals with a variant of E23K polymorphism of potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) gene. Egypt J Med Human Genet. 2014;16:227-31.

International Diabetes Federation/IDF. 2011. Available at: https://idf.org/. Accessed on 10 February 2021.

Haghvirdizadeh, P, Mohamed, Z, Abdulla, NA, Haghvirdizadeh, P, Haerian, MS, Haerian, BS. KCNJ11: genetic polymorphism and risk of diabetes mellitus. J Diab Res. 2014;1-9.

Aschroft, FM. ATP-sensitive potassium channelopathies: focus on insulin secretion. JCI. 2005;115:2047-58.

Ezenwaka, C, Kalloo, R, Uhlig, M, Schwenk, R, Eckel, J. The E23K variant in the Kir6.2 subunit of the ATP-sensitive K channel does not augment impaired glucose tolerance in Caribbean subjects with a family history of type 2 diabetes. J Endocrin. 2005;185:439-44.

Downloads

Published

2021-07-28

How to Cite

Maay, J. K. R., Hastuti, P., & Sadewa, A. H. (2021). Correlation of E23K gena KCNJ11 polymorphism as a Risk Factor for Obesity with Type 2 Diabetes Mellitus In Jayapura, Papua. International Journal of Research in Medical Sciences, 9(8), 2201–2209. https://doi.org/10.18203/2320-6012.ijrms20212804

Issue

Section

Original Research Articles