Study of insulin status in metabolic syndrome in correlation with presence of other risk factors


  • Sudhanshu Shekhar Department of Biochemistry, Narayan Medical College and Hospital, Sasaram, Bihar
  • Ram Ranjan Singh Department of Biochemistry, Lord Buddha Koshi Medical College & Hospital, Saharsa, Bihar
  • Md. Jawed Akhtar Department of Anatomy, Indira Gandhi Institute of Medical Sciences, Patna, Bihar
  • Vijay Shankar Department of Surgery, Lord Buddha Koshi Medical College & Hospital, Saharsa, Bihar



Insulin, Metabolic syndrome, Diabetes, Hypertension


Background: The metabolic syndrome or insulin resistance syndrome is widely prevalent and multifactorial disorder. The majority of persons with metabolic syndrome have insulin resistance. Insulin resistance and / or associated hyperinsulinemia are believed to be the direct cause of other metabolic syndrome risk factors. The present work is being done to assess the insulin status and to assess the correlation between insulin status and other component of metabolic syndrome.

Methods: The present work is being carried out in 112 cases of metabolic syndrome, defined as per modified NCEP ATP III (MS-4) criteria. Serum insulin of all cases was measured by chemiluminescent microparticle immunoassay (CMIA) technique.

Results: It was observed that 62% of the patients of metabolic syndrome had elevated serum insulin level (Hyperinsulinemia). Hyperinsulinemia was found to be significantly associated with diastolic hypertension and HDL in males. A high association was also noted with BMI.  Insulin resistance (HOMA-IR >2.50) was significantly associated with waist circumference in males (p value<0.05).

Conclusions: It was observed that metabolic syndrome is associated with elevated serum insulin levels and each component of metabolic syndrome, both biochemical as well as clinical, is associated with hyper-insulinemia and this reflects the presence of insulin resistance in subjects of study.



Lau DC. Metabolic syndrome: perception or reality? Curr Atheroscler Rep. 2009;11(4):264-71.

Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome: Circulation. 2005;112:285-90.

Reddy KS, Prabhakaran D. Methods for establishing a surveillance system for CVD in industrial population in India .Bulletin of World Health Organization. 2006;461-69.

Grundy S, Brewer B, Cleeman J, Smith S and Lenfant C. Definition of metabolic syndrome: Circulation. 2004;109:433-38.

Eckel R, Grundy S, Zimmet. The metabolic syndrome. The Lancet. 2005;365(9468):1415-28.

Sun H Kim, Gerald M Reaven. Insulin Resistance and Hyperinsulinemia. Diabetes Care. 2008;31(7):1433-8.

Gill H, Mugo M, Whaley Connell A, Stump C, Sowers J. The key role of insulin resistance in the cardiometabolic syndrome. The American Journal of the Medical Sciences. 2005;330(6):290-4.

Morse S, Zhang R, Thakur V, Reisin E. Hypertension and the metabolic syndrome. American Journal of the Medical Sciences. 2005:330(6);303-10.

Misra A, Wasir JS, Pandey RM. An evaluation of candidate definition of metabolic syndrome in adult Asian Indians. Diabetes Care. 2005;28(2):398-403.

Katsuki A, Sumida Y, Gabazza EC, Murashima S. Homeostasis model assessment is a reliable indicator of insulin resistance during followup of patients with Type 2 Diabetes. Diabetes care. 2001;24(2):362-5.

Ribeiro-Filho FF, Faria AN, Kohlmann NE, Zanella MT, Ferreira SR. Two hour insulin determination improves the ability of abdominal fat measurement to identify risk factor for the metabolic syndrome. Diabetes care. 2003;26:1725-30.

Kawada T, Inagaki H, Wakayama Y, Qing Li. Serum insulin is significantly related to components of the metabolic syndrome in Japanese working men. The Journal of Clinical Hypertension. 2010(4):309-14.

Hemalatha R, Annapurna VV, Damayanthi K, Radhakrishna KV. Substantial proportion of apparently healthy, urban south Indian young adults has insulin resistance associated with other cardiovascular risk factors. Journal of Medical Sciences. 2010;3(2):110-7.

Reaven GM. Banting Lecture. Role of insulin resistance in human diseases. Diabetes. 1988;37:1595-607.

Mitchell BD, Haffner SM, Hazuda HP, Valdez R. The relation between serum insulin levels and 8 year changes in lipid, lipoprotein, and blood pressure levels. Am J Epidemiol. 1992;136(1):12-22.

Deepa R, Shanthirani CS, Premalatha G, Sastry NG, Mohan V. Prevalence of insulin resistance syndrome in a selected south Indian population – the Chennai urban populations study 7 (CUPS7). Indian J Med Res. 2002;115:118-27.

Wahrenberg H, Hertel K, Leijonhufv BM, Toft E. Use of waist circumference to predict insulin resistance: retrospective study. BMJ. 2005;330:1363-4.

Steele A, Sheilds B, Knight B and Pearson E. Waist circumference: Apredictive tool for insulin resistance. Journal of Diabetes Nursing. 2005;9(10):389-93.




How to Cite

Shekhar, S., Singh, R. R., Akhtar, M. J., & Shankar, V. (2017). Study of insulin status in metabolic syndrome in correlation with presence of other risk factors. International Journal of Research in Medical Sciences, 4(7), 2734–2737.



Original Research Articles