Use of chronic lymphocytic leukemia-international prognostic index in patient risk stratification-single center experience

Authors

  • Sanja Trajkova PHI University Clinic for Hematology-Skopje, Medical Faculty, University Ss. Cyril and Methodius, Skopje, Republic of Northern Macedonia
  • Lidija Cevreska PHI University Clinic for Hematology-Skopje, Medical Faculty, University Ss. Cyril and Methodius, Skopje, Republic of Northern Macedonia
  • Svetlana Krstevska -Balkanov PHI University Clinic for Hematology-Skopje, Medical Faculty, University Ss. Cyril and Methodius, Skopje, Republic of Northern Macedonia
  • Aleksandra Pivkova -Veljanovska PHI University Clinic for Hematology-Skopje, Medical Faculty, University Ss. Cyril and Methodius, Skopje, Republic of Northern Macedonia
  • Marija Popova-Labacevska PHI University Clinic for Hematology-Skopje, Medical Faculty, University Ss. Cyril and Methodius, Skopje, Republic of Northern Macedonia
  • Aleksandra Jovanovska PHI University Clinic for Child Diseases-Skopje, Medical Faculty, University Ss. Cyril and Methodius, Skopje, Republic of Northern Macedonia
  • Nevenka Ridova PHI University Clinic for Hematology-Skopje, Medical Faculty, University Ss. Cyril and Methodius, Skopje, Republic of Northern Macedonia
  • Simona Stojanovska PHI University Clinic for Hematology-Skopje, Medical Faculty, University Ss. Cyril and Methodius, Skopje, Republic of Northern Macedonia
  • Irina Panovska-Stavridis PHI University Clinic for Hematology-Skopje, Medical Faculty, University Ss. Cyril and Methodius, Skopje, Republic of Northern Macedonia

DOI:

https://doi.org/10.18203/2320-6012.ijrms20213406

Keywords:

CLL-IPI, Risk stratification, Survival

Abstract

Background: Several prognostic factors have been identified to predict the outcome of patients with chronic lymphocytic leukemia (CLL). To predict the time to first treatment (TFT) we integrated the data of clinical and biological markers in CLL-International prognostic index (CLL-IPI). Aim of the study was the determination of the impact of CLL-IPI in prediction of TFS in CLL patents.

Methods: The study was set up retrospectively and included 90 patients with CLL diagnosed and treated at the university clinic of hematology for a period of time from January 2012 to January 2020. We incorporated the data of Binet staging system, most adverse cytogenetic marker and mutational status of immunoglobulin heavy chain in CLL-IPI.

Results: The statistical data of the 90 patients showed that the median TFS for low CLL-IPI (N=24), intermediate CLL-IPI (N=40), high risk CLL-IPI (N=17) and very high risk group (N=9) according to the CLL-IPI scoring system was 20.1, 17.6, 7.1 and 5.8 months, respectively. Multivariate analysis indicated that del 17p (p<0.008) was independent prognostic factors of TFS.

Conclusions: CLL-IPI is a powerful risk stratification tool for CLL patients and this system has also provided treatment recommendations for different patient risk subgroups.

 

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Published

2021-08-25

How to Cite

Trajkova, S., Cevreska, L., Krstevska -Balkanov, S., Pivkova -Veljanovska, A., Popova-Labacevska, M., Jovanovska, A., Ridova, N., Stojanovska, S., & Panovska-Stavridis, I. (2021). Use of chronic lymphocytic leukemia-international prognostic index in patient risk stratification-single center experience. International Journal of Research in Medical Sciences, 9(9), 2673–2680. https://doi.org/10.18203/2320-6012.ijrms20213406

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Original Research Articles