Investigation of clinical parameters associated with COVID-19 in pregnant women
DOI:
https://doi.org/10.18203/2320-6012.ijrms20213411Keywords:
Pregnancy, Diabetes, Hypertension, Pregnant females, SpO2, SARS-CoV-2Abstract
Background: Pregnancy is an immune-compromised condition; encompass physiological changes that make the women more vulnerable to infections such as COVID-19. The major concern is about the intrauterine transmission resulting in fetal and neonatal outcomes; therefore, this group of population requires more attention pertaining prevention, management and treatment. Thus, the main aim of the study is to analyze clinical characteristics among pregnant women.
Methods: The study was conducted on 17092 samples of pregnant adults whose nasopharyngeal and/or oropharyngeal swab samples were received from various districts of Punjab (Amritsar, Gurdaspur, Hoshiarpur, Kapurthala, Tarn Taran and Pathankot) from the period of March 2020 to December 2020. Confirmation of SAS-CoV-2 was done by RT-PCR.
Results: Out of total samples (17092), 374 (2.19%) females exhibited positive results for SARS-CoV-2, and mean age of the pregnant females was 26.37 years. Analysis was performed on 210 (Positive) samples as cases and 210 age matched control females (SARS-CoV-2 negative). Analysis performed demonstrated that SpO2 <96% and co-morbidities such as diabetes and hypertension showed significant association and are common factors in COVID-19. None of the case showed any neonatal and maternal demise.
Conclusions: In the present study, saturation level of oxygen (<96%), diabetes and hypertension was found to be significant. All the pregnant women have similar symptoms as that of non pregnant adults.
References
Swartz D, Graham A. Potential maternal and infant outcomes from coronavirus 2019-nCoV (SARS-CoV-2) infecting pregnant women: lessons from SARS, MERS, and Other Human Coronavirus. Infect Virus. 2020;12(2):1-16.
Liang H, Acharya G. Novel corona virus disease (COVID-19) in pregnancy: What clinical recommendations to follow? Acta Obstet Gynecol Scand. 2020;99(4):439-42.
Clinical management of severe acute respiratory infection when Novel coronavirus (2019-nCoV) infection is suspected. Available At: https://www. who.int/publications-detail/clinical management of severe acute respiratory infection when novel coronavirus infection is suspected. Accessed on 28 February 2021.
Alfaraj SH, Al-Tawfiq JA, Memish ZA. Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection during pregnancy: Report of two cases & review of the literature. J Microbiol Immunol Infect. 2019;52(3):501-3.
Mullins E, Evans D, Viner R ,O'Brien P, Morris E. Coronavirus in pregnancy and delivery: rapid review and expert consensus. Ultrasound Obstet Gynecol. 2020;55:586-92.
Aggarwal A, Sidhu SK, Nagpal N, Kaur A, Jairath M, Sharma M, Singh K. Clinical and demographic profile of elderly population with sars-cov-2 from two districts of Doaba region of Punjab. Indian J App Res. 2021;11(2):81-3.
Yang H, Wang C, Poon C. Novel coronavirus infection and pregnancy. Ultrasound Obstet Gynecol. 2020;55:435-7.
Li Q, Guan X, Wu P. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med. 2020;382:1199-207.
Liu H, Liu F, Li J, Zhang T, Wang D, Lan W. Clinical and CT imaging features of the COVID-19 pneumonia: Focus on pregnant women and children. J Infect. 2020;80(5):E7-13.
Caron C, Van Syckle K. The babies were delivered. No one realized the mothers had the virus. Available at: https://www.nytimes.com/2020/03/27/parenting/ nyc-coronavirus-hospitals-delivery.html. Accessed on 20 May 2021.
Sattari M, Bashirian S, Masoumi SZ, Shayan A, Jenabi E, Ghelichkhani S, et al. Evaluating clinical course and risk factors of infection and demographic characteristics of pregnant women with COVID-19 in Hamadan Province, West of Iran. J Res Health Sci. 2020;20(3):e00488.
Chen HGJ, Wang C, Luo F, Yu X, Zhang W, Li J, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395(10226):809-15.
Martinez-Portilla RJ, Sotriadis A, Torres S, Christos C, Hawkins-Villarreal A, et al. Risk factors for mortality in pregnant women with SARS-CoV-2 infection. J Infect. 2020;42:45-9.
Allotey J, Stallings E, Bonet M. Clinical manifestations, risk factors and maternal and paternal outcomes of coronavirus disease 2019 in pregnancy: living systemic review and meta analysis. BMJ. 2020;370:m3320.
Jordan RE, Adab P, Cheng KK. Covid-19: risk factors for severe disease and death. BMJ. 2020;368:m1198.
Ellington S, Strid P, Tong VT. Centers for disease control and prevention. characteristics of women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status-United States. MMWR Morb Mortal Wkly Rep. 2020; 69(25):769-75.
Stephansson O, Petersson K, Bjork C, Conner P, Wikstrom AK. The Swedish Pregnancy Register -for quality of care improvement and research. Acta Obstet Gynecol Scand. 2018;97:466-76.
Yan J, Guo J, Fan C. Coronavirus disease 2019 (COVID-19) in pregnant women: A report based on 116 cases. Am J Obstet Gynecol. 2020;223:e1-e14.
Ferrazzi E, Frigerio L, Savasi V. Vaginal delivery in SARS-CoV-2 infected pregnant women in Northern Italy: a retrospective analysis. BJOG. 2020;127(9):1116-21.
Sentilhes L, De Marcillac F, Jouffrieau C, Kuhn P, Thuet V, Hansmann Y, et al. Coronavirus disease 2019 in pregnancy was associated with maternal morbidity and preterm birth. Am J Obstet Gynecol. 2020;223(6):e1-15.
Wang X, Zhou Z, Zhang J, Zhu F, Tang Y, Shen X. A case of 2019 novel coronavirus in a pregnant woman with preterm delivery. Clin Infect Dis. 2020; 71(15):844-6.
Zhang L, Jiang Y, Wei M, Cheng B, Zhou X, Li J, et al. Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province. Zhonghua Fu Chan Ke Za Zhi. 2020;55(3):166-71.
Qiancheng X, Jian S, Lingling P, Lei H, Xiaogan J, Weihua L, et al. Coronavirus disease 2019 in pregnancy. Int J Infect Dis. 2020;95(2020):376-38.
Khan MA, Khan N, Mustagir G, Rana J, Haque R, Rahman M. COVID-19 infection during pregnancy: A systematic review to summarize possible symptoms, treatments, and pregnancy outcomes. MedRxiv. 2020;2020:45-9.
