@article{Wagh_Rajopadhye_Mukherjee_Urhekar_Modi_2017, title={Assessment of oxidative stress in serum of pulmonary tuberculosis patients}, volume={4}, url={https://www.msjonline.org/index.php/ijrms/article/view/1129}, DOI={10.18203/2320-6012.ijrms20162288}, abstractNote={<p class="abstract"><strong>Background:</strong> Tuberculosis (TB) remains a human health issue and often deadly infectious disease in low-middle income nations. In TB, oxidative stress is a result of tissue inflammation, poor dietary intake of micronutrients due to illness, free radical burst from activated macrophages. This study was conducted prospectively to evaluate the oxidative stress in TB.</p><p class="abstract"><strong>Methods:</strong> The study included 30 newly diagnosed TB positive patients and 30 healthy individuals. Pro-oxidant markers like the thiobarbituric acid reactive species (TBARS) and nitric oxide were studied from serum. Antioxidant parameter like serum total-SH was also assessed.</p><p class="abstract"><strong>Results:</strong> Levels of pro-oxidants were significantly increased whereas antioxidant defense markers were significantly impaired in the TB group. Nitric oxide and TBARS were increased (p<0.0001) where glutathione was decreased (p<0.0001) in TB population compared to healthy controls.</p><p class="abstract"><strong>Conclusions:</strong> Marked oxidative stress were seen in the TB population as compared to the healthy cohort. The role of antioxidant therapy may therefore be evaluated in the management of TB.  </p><p class="abstract"> </p>}, number={8}, journal={International Journal of Research in Medical Sciences}, author={Wagh, Vishal and Rajopadhye, Shreewardhan and Mukherjee, Sandeepan and Urhekar, Anant and Modi, Deepak}, year={2017}, month={Jan.}, pages={3328–3332} }