@article{Bramhabhatt_Jha_Faruqui_2017, title={Evaluation of efficacy and safety of oral olmesartan + chlorthalidone combination in the management of hypertension in Indian patients}, volume={3}, url={https://www.msjonline.org/index.php/ijrms/article/view/1347}, abstractNote={<p class="abstract"><strong>Background:</strong> Hypertension is a major health problem in India. Being a multifactorial condition often requires the administration of multiple drugs. Despite improvements in the management of hypertension and the availability of effective antihypertensive agents, only 50% of these individuals achieve BP control. The present study was undertaken to evaluate the efficacy and safety of, fixed dose combination of olmesartan 40 mg + chlorthalidone 12.5 mg, in the management of hypertension uncontrolled with olmesartan monotherapy.</p><p class="abstract"><strong>Methods:</strong> 110 patients were enrolled in this Post-Marketing Surveillance (PMS) study. Patients were prescribed to take fixed dose combination for 60 days.</p><p class="abstract"><strong>Results:</strong> There was significant decrease (P <0.0001) in Systolic Blood Pressure (SBP) & Diastolic Blood Pressure (DBP) from the baseline to 15<sup>th</sup>, 30<sup>th</sup> and 60<sup>th</sup> days of the treatment. At the end of the study period of 60 days 95.4% & 90.9% patients of age group >60 years and <60 years achieved the Joint National Committee (JNC VIII) recommended goal respectively. (<150/90 for elder patients aged above 60 year and 140/90 for those aged less than 60 years).</p><p class="abstract"><strong>Conclusion:</strong> Thus fixed dose combination therapy of olmesartan & chlorthalidone has been shown to be excellent in efficacy and tolerability & gives another option for the optimal management of hypertension.</p><p class="abstract"> </p>}, number={3}, journal={International Journal of Research in Medical Sciences}, author={Bramhabhatt, Vijay and Jha, Manoj Kumar and Faruqui, Arif A.}, year={2017}, month={Jan.}, pages={640–644} }