@article{B._T._S.V._Kindo_2017, title={Pattern of susceptibility to azoles by E test method in candidemia patients}, volume={3}, url={https://www.msjonline.org/index.php/ijrms/article/view/1666}, DOI={10.18203/2320-6012.ijrms20150337}, abstractNote={<p class="abstract"><strong>Background:</strong> Blood stream infections due to <em>Candida sp</em> have considerably increased in recent years, along with the increase of drug-resistant isolates in immunocompromised patients. This increase in resistance makes it important to determine the antifungal susceptibility profile of each <em>Candida</em> species isolated from blood prior to treatment. Hence, this study was done to detect the resistant strains of <em>Candida</em> causing candidemia.</p><p class="abstract"><strong>Methods:</strong> About Seventy <em>Candida</em> species isolated from blood cultures were used for this study. These included 27 <em>Candida albicans</em>, 23 <em>Candida tropicalis</em>, 8 <em>Candida parapsilosis</em>, 3 <em>Candida krusei</em>, 2 <em>Candida glabrata</em> and 7 other candida species. Minimum inhibitory concentrations (MIC) of the most commonly used azoles like fluconazole, ketoconazole, itraconazole and voriconazole were determined by E test method.</p><p class="abstract"><strong>Results:</strong> The resistance percentage of <em>Candida albicans</em> for fluconazole and itraconazole was 11.1% and 7.4%; fluconazole resistance in <em>Candida tropicals</em> was 8.7%. <em>Candida parapsilosis</em> had good activity against all azoles with only 12.5% resistance for itraconazole.</p><p class="abstract"><strong>Conclusions:</strong> Fluconazole had good activity against most of the Candida sp except for <em>Candida glabrata</em> and <em>Candida krusei</em> with MIC 90 > 256 µg/ml. Itraconazole was less effective for <em>Candida albicans</em>, <em>Candida glabrata</em> and <em>Candida parapsilosis</em> (MIC 90 >32 µg/ml). Voriconazole was found to be the most effective drug against all species of <em>Candida </em>with low MIC values (MIC 90 < 0.25 µg/ml). Hence it can be used to treat blood stream infections caused by <em>Candida</em> species.</p><p class="abstract"> </p>}, number={8}, journal={International Journal of Research in Medical Sciences}, author={B., Sri Janani and T., Premamalini and S.V., Rajyoganandh and Kindo, Anupma J.}, year={2017}, month={Jan.}, pages={2118–2122} }