@article{K. M._K. C._G._Basavegowda_Debnath_M.G._2016, title={Pattern of vitamin D status in prediabetic individuals: a case control study at tertiary hospital in South India}, volume={4}, url={https://www.msjonline.org/index.php/ijrms/article/view/637}, DOI={10.18203/2320-6012.ijrms20160706}, abstractNote={<p class="abstract"><strong>Background:</strong> Role of vitamin D in the regulation of calcium metabolism is well established. Vitamin D deficiency has been linked to impaired glucose tolerance and type 2 DM in humans. There is a limited available data on the relationship of vitamin D insufficiency/deficiency with glucose homeostasis among prediabetic individuals in South Indian population. Hence we examined serum 25(OH) D<sub>3</sub> concentration among prediabetics. The objective of this study is to evaluate prevalence of vitamin D deficiency in prediabetics and to study any correlation between vitamin D and BMI, FBS and PPBS among prediabetics.  </p><p class="abstract"><strong>Methods:</strong> A case control study was carried out among 40 prediabetics & controls, after obtaining consent from subjects and clearance from institutional ethics committee. Serum vitamin D levels were measured by radioimmunoassay in both groups. Statistical analysis was done using “t” test & Pearson correlation co-efficient (r).</p><p class="abstract"><strong>Results:</strong> Vitamin D levels less than 20 ng/ml were found in 72.5% of cases and 35% of controls. 5% of the cases and 12.5% of the controls had vitamin D above 30 ng/ml and this difference was statistically significant. Mean vitamin D levels in cases and controls was 17.09±5.89 ng/ml and 23.67±11.02 ng/ml respectively (P<0.05). A significant inverse correlation was observed between vitamin D levels & body mass index (r=-0.274; p=0.014); random blood sugar (r=-0.35; p=0.001); fasting blood sugar (r=-0.328; p=0.003); post prandial blood sugar (r=-0.276; p=0.013).</p><p class="abstract"><strong>Conclusions:</strong> High prevalence of hypovitaminosis D exists among prediabetics and there is significant inverse correlation between BMI, FBS, PPBS and vitamin D levels. Hence, a prospective study covering large pre-diabetic individuals is essential to confirm the findings.</p><p class="abstract"> </p>}, number={4}, journal={International Journal of Research in Medical Sciences}, author={K. M., Srinath and K. C., Shashidhara and G., Rajeev Reddy and Basavegowda, Madhu and Debnath, Kishaloy and M.G., Mahesh}, year={2016}, month={Dec.}, pages={1010–1015} }