TY - JOUR AU - Kannan, J. AU - Saklani, Amit AU - Mohanty, Srigopal AU - Narapaneni, Kiranmayee AU - George, Deepak AU - Ingersal, N. PY - 2021/12/28 Y2 - 2024/03/29 TI - The pattern of distant metastasis and clinicopathological factors associated with de-novo metastatic cervical cancer: a retrospective analysis JF - International Journal of Research in Medical Sciences JA - Int J Res Med Sci VL - 10 IS - 1 SE - Original Research Articles DO - 10.18203/2320-6012.ijrms20215053 UR - https://www.msjonline.org/index.php/ijrms/article/view/10367 SP - 191-195 AB - <p class="abstract"><strong>Background:</strong> Metastatic cervical cancer carries poor prognosis. The factors associated with distant metastasis in newly diagnosed cervical cancer patients are not clear.</p><p class="abstract"><strong>Methods:</strong> A retrospective analytical study was performed to study the pattern of distant metastasis, and to evaluate the factors associated with de-novo metastatic cervical cancer. Univariate and multivariate analysis (by MANOVA) were used to evaluate the association. P≤0.05 was considered significant.</p><p class="abstract"><strong>Results: </strong>Out of 1321 newly diagnosed cervical cancer patients, 54 (4.1%) had de-novo metastatic disease and most of which (81%) were found at single site. Common sites of distant metastasis were non-regional nodes, followed by liver, lung, peritoneum and bone. Univariate analysis showed the factors associated with de-novo metastasis were non squamous subtype, high grade histology, bulky primary tumor (&gt;4 cm), pelvic/para-aortic lymphadenopathy, and hydroureteronephrosis. Multivariate analysis revealed the factors associated with de-novo metastasis were bulky primary tumor (&gt;4 cm), high grade histology, pelvic/para aortic lymphadenopathy, hydroureteronephrosis.</p><p class="abstract"><strong>Conclusions: </strong>Newly diagnosed cervical cancer patients with bulky primary tumor, high grade histology, pelvic or para aortic lymphadenopathy, hydroureteronephrosis are associated with higher risk of de-novo distant metastasis.</p> ER -