TY - JOUR AU - Agarwal, Nitin AU - Gangopadhyay, Sukanya AU - Koch, Nirensingh AU - Gupta, Akash AU - Batra, Aruna AU - Kabi, B. C. PY - 2017/01/09 Y2 - 2024/03/29 TI - Polycystic ovarian syndrome and insulin resistance: a North Indian study JF - International Journal of Research in Medical Sciences JA - Int J Res Med Sci VL - 3 IS - 6 SE - Original Research Articles DO - 10.18203/2320-6012.ijrms20150139 UR - https://www.msjonline.org/index.php/ijrms/article/view/1493 SP - 1321-1324 AB - <p class="abstract"><strong><span lang="EN-US">Background</span></strong><strong><span lang="EN-US">:</span></strong><span lang="EN-US"> Polycystic ovarian syndrome (PCOS) is most common form of chronic anovulation associated with androgen excess. Insulin resistance (IR) is characterized by impaired glucose response to specific amount of insulin. The objective of the study was to find an association between PCOS and IR in North Indian patients.</span></p><p class="abstract"><strong><span lang="EN-US">Methods</span></strong><strong><span lang="EN-US">:</span></strong><span lang="EN-US"> A total of 50 PCOS cases diagnosed according to Rotterdam criteria, 2003, i.e. at least two of the following three features: oligomenorrhea or amenorrhea, clinical or biochemical hyperandrogenism and polycystic ovaries on ultrasound. Serum glucose levels were measured spectrophotometrically by glucose oxidase-peroxidase method. Insulin levels in serum were estimated by using ELISA based kit procured form Diasorin Ltd, Germany. Homeostatic Model Assessment- Insulin Resistance (HOMA-IR) and Body Mass Index (BMI) were calculated by their formulas. </span></p><p class="abstract"><strong><span lang="EN-US">Results</span></strong><strong><span lang="EN-US">:</span></strong><span lang="EN-US"> PCOS patients had significantly higher values of BMI, fasting serum glucose, fasting serum insulin and HOMA-IR. Fasting serum glucose was however in the normal range in both cases and control.</span></p><p class="abstract"><strong><span lang="EN-US">Conclusion: </span></strong><span lang="EN-US">Our study suggested a strong association of PCOS with insulin resistance in this part of the country.</span></p><p class="abstract"> </p> ER -