TY - JOUR AU - Maulidan, Yasser AU - Syamsu, Salman A. AU - Thabry, Rudy AU - Abidin, Zainal PY - 2019/06/28 Y2 - 2024/03/28 TI - Correlation cyclooxygenase-2 expression and histopathological grading in locally advanced breast cancer JF - International Journal of Research in Medical Sciences JA - Int J Res Med Sci VL - 7 IS - 7 SE - Original Research Articles DO - 10.18203/2320-6012.ijrms20192884 UR - https://www.msjonline.org/index.php/ijrms/article/view/6589 SP - 2595-2598 AB - <p class="abstract"><strong>Background:</strong> Cyclooxygenase-2 (COX-2) is involved in the carcinogenesis process and tumor progression into cancer. It has been reported recently, there was a COX-2 expression at breast cancer. Patients with a high level of COX-2 expression can have a local recurrence and decrease life expectancy, and an increase of COX-2 expression in tissue likelihood has prognostic value. This study aims to correlation cyclooxygenase-2 (cox-2) expression and histopathological grading in locally advanced breast cancer patient in AW Sjahranie Hospital in Samarinda city.</p><p class="abstract"><strong>Methods:</strong> This study was an observational study with crossectional design to analysis the correlation COX-2 expression and histopathological grading in patients with locally advanced breast cancer and using data analysis with the Chi-Square test.</p><p class="abstract"><strong>Results:</strong> The results showed that the correlation was not significant (P&gt;0.05), where there was no correlation of COX-2 expression with histopathological grading (P=0.221) and there was no correlation with the last condition of patients (P=0.61). Although patients with breast cancer high grade and moderate grade percentages were significantly higher in positive COX-2 than in COX-2 negative expression.</p><p class="abstract"><strong>Conclusions:</strong> There were no correlation between COX-2 expression and histopathological grading and there was no significant relationship between COX-2 expression and the last condition, as evidenced by the statistical test results showing that the differences were not significant.</p> ER -