TY - JOUR AU - Murmu, Akash R. AU - R., Mubarak PY - 2021/05/27 Y2 - 2024/03/29 TI - Correlation between serum ferritin level and severity of dengue fever in a tertiary care center: an observational study JF - International Journal of Research in Medical Sciences JA - Int J Res Med Sci VL - 9 IS - 6 SE - Original Research Articles DO - 10.18203/2320-6012.ijrms20212244 UR - https://www.msjonline.org/index.php/ijrms/article/view/9627 SP - 1735-1740 AB - <p><strong>Background:</strong> Serum ferritin is an acute phase protein and elevated levels of ferritin have been associated with the pathogenesis of many inflammatory infectious viral diseases. Dengue is a mosquito-borne tropical infection that caused by the dengue virus. TNFα and interleukin 1α, another proinflammatory cytokine, transcriptionally induce the H-chain of ferritin. Therefore, serum ferritin can be used as a prognostic marker for dengue severity.</p><p><strong>Methods:</strong> This is a case control study conducted between July 2017 to December 2018.</p><p><strong>Results:</strong> On the 3rd day of fever, the median values of serum ferritin in dengue, fever without warning signs, with warning signs, and severe dengue were 513.5 ng/ml, 1002 ng/ml and 2352.4 ng/ml respectively. On the 7th day of fever, the median values were 474 ng/ml, 900 ng/ml, and 2949 ng/ml respectively. Serum ferritin 1247 ng/ml on day 3 has a sensitivity of 96.4% and specificity of 91% for prediction of severity. Area under the curve for serum ferritin on day 3 was 0.963 (95% confidence limit: 0.934-0.991). Serum ferritin 1050 ng/ml on day 7 has a sensitivity of 98.2 % and specificity of 93% for prediction of severity. Area under the curve for serum ferritin on day 7 was 0.977 (95% confidence limit: 0.957-0.998).</p><p><strong>Conclusions:</strong> Elevation of serum ferritin was significantly seen in those with severe dengue. Serum ferritin can be used as a prognostic marker for dengue severity. Day 3 serum ferritin can be used as a prognostic marker for dengue severity.</p> ER -