Non symptomatic hypoglycemia in cancer patients: a case series in a tertiary care cancer hospital

Kuldeep Kumar Gupta; Pratibha Gavel; Priyanka Asia; Nirupam Mohapatra

doi:10.18203/2320-6012.ijrms20232436

Authors

Kuldeep Kumar Gupta Department of Biochemistry, UNS ASMC, Jaunpur, Uttar Pradesh, India
Pratibha Gavel Department of Biochemistry, Homi Bhabha Cancer Hospital, Varanasi, Uttar Pradesh, India
Priyanka Asia Department of Biochemistry, Homi Bhabha Cancer Hospital, Varanasi, Uttar Pradesh, India
Nirupam Mohapatra Department of Biochemistry, Homi Bhabha Cancer Hospital, Varanasi, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20232436

Keywords:

Hypoglycemia, Warburg effect, Ketone bodies

Abstract

Sever hypoglycemia when blood glucose level <54 mg/dl is a grave condition and patients manifest with impaired cognitive function. Glucose is the key energy source for brain. In normal physiological condition glucose metabolized aerobically to produce energy in the form of ATP after glycolysis. In hypoglycemia like in condition of starvation or in any pathologically low blood glucose level, brain depends on ketone bodies to fulfill its energy requirement. In cancer patients due to Warburg effect there is aerobic fermentation of glucose leads to production of ketone bodies and lactic acid, which fulfill the energy requirement of brain and patients doesn't show symptoms of hypoglycemia

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