A comparative study for management of fissure in ano with glycerin-trinitrate and lignocaine ointment: a randomized control trial

Authors

  • Kamlesh J. Galani Department of Surgery, C. U. Shah Medical College, Surendranagar, Gujarat, India
  • Ashwinkumar S. Gadhvi Department of Surgery, C. U. Shah Medical College, Surendranagar, Gujarat, India
  • Nidhi D. Shah Department of Surgery, C. U. Shah Medical College, Surendranagar, Gujarat, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20183244

Keywords:

Anal fissure, Glycerin-trinitrate, Lignocaine

Abstract

Background: Anal fissure is a very common benign anorectal disorder with significant morbidity among otherwise healthy individuals. Of all the patients coming to our OPD 15-20% have anal fissure. So there arises need to study the best and most compliant conservative treatment modality.

Methods: Study was randomized, prospective, observational and longitudinal including 200 patients of age group 18-60 equally divided in 2 groups. Group A given 0.2% GTN ointment and group B given lignocaine ointment.

Results: Better and early and sustained symptomatic relief was noted with GTN compared to lignocaine. 80% cases showed complete healing by 8 weeks with GTN compared to 52% healing with lignocaine. Headache was main side effect with GTN. Recurrence rate was high with lignocaine.

Conclusions: Topical GTN has a statistically and clinically significant success rate for fissure healing and pain improvement at 8 weeks compared to lignocaine ointment (80% vs. 52%). It came at the cost of clinically acceptable level of morbidity (headache).

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References

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Published

2018-07-25

How to Cite

Galani, K. J., Gadhvi, A. S., & Shah, N. D. (2018). A comparative study for management of fissure in ano with glycerin-trinitrate and lignocaine ointment: a randomized control trial. International Journal of Research in Medical Sciences, 6(8), 2644–2647. https://doi.org/10.18203/2320-6012.ijrms20183244

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Original Research Articles