Published: 2017-01-02

Cyto-histopathological correlation in palpable breast lesions

Kuldeep Mehra, Vanita Kumar, Rajvinder Kaur, Neelu Gupta


Background: Breast lesions are one of the most commonly encountered lesions in women which require prompt pathological confirmation by fine needle aspiration cytology (FNAC) and histopathological examination.

Methods: We conducted a prospective study from January 2015 to December 2015. A total 98 cases included presenting with palpable breast lump in which 80 cases were also subjected to surgical biopsy or mastectomy.

Results: Out of 98 cases, 34.7% benign cases, 59.2% malignant cases, and 6.1% non-neoplastic case were diagnosed cytologically in which 7 (7.1%) cases of mastitis, 2 cases (2%) of granulomatous mastitis, 22 cases (22.4%) of fibroadenoma, 11 cases (11.2%) of benign breast disease or fibrocystic disease, 10 (10.2%) cases of dyskaryotic changes , 45 cases (45.9%) carcinoma. Mean age was 46.4±14.2 years. Majority of cases 29(29.6%) belonged to 41-50 years age group. Majority of the masses were situated in the left breast (57.2%) in the upper outer quadrant (40.8%). In addition to breast lump, pain in 22 cases, bloody discharge in 5 cases, ulceration in 8 cases and nipple retraction in 11 cases were present. Histology was available for 80 cases in which 5 (6.3%) cases of non-neoplastic, 27 cases (33.7%) benign and 48 cases (60%) of malignant histology. FNAC proved to be 91.25 % sensitivity in the diagnosis of all breast lesions in our study.

Conclusions: So we concluded that breast lesions are easily accessible to FNAC, which is an easy, cost effective and less time-consuming procedure. FNAC is used to diagnose both benign and malignant lesions.



Breast, Cyto-histological correlation, Ductal carcinoma, FNAC Breast

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Cangiarella J, Simsir A. Breast. In: Orell SR, Sterrett GF, Whitaker D, editors. Fine Needle Aspiration Cytology. 4th ed. New Delhi, India: Elsevier Publication. 2005;165-217.

Orell SR, Sterrett GF, Whitaker D. In Orell SR, Sterrett GF, Whitaker D. Fine Needle Aspiration Cytology. 4th Ed. New Delhi. Elsevier Publication; 2005;165-6

Pattari SK, Dey P, Gupta SK, Joshi K. Myoepithelial cells: Any role in aspiration cytology smears of breast tumours? Cytojournal. 2008;5:9.

Jayaram G, Alhady SF, Yip CH. Cytological analysis of breast lesions: A review of 780 cases. Malaysian J Pathol. 1996;18:81-7.

Khanna R, Khanna S, Chaturvedi S, Arya NC. Spectrum of breast disease in young females; a retrospective study of 1315 patients. Indian J Pathol Microbiol. 1998;41(4):397-401.

Bhargava V, Jain M, Agarwal K, Thomas S, Singh S. Critical appraisal of cytological nuclear grading in carcinoma of the breast and its correlation with ER/PR expression. Journal of Cytology 2008;25(2):58-61.

Doussal VL, Tubiana-Hulin M, Friedman S, Hacene K, Spyratos F, Brunet M. Prognostic value of histological grade nuclear components of Scarff Bloom Richardson (SBR). An improved score modification based on a multivariate analysis of 1262 invasive ductal carcinoma. Cancer 1989;64:1914-21.

Ganiat O, Omoniyi-Esan G, Osasan S, Titiloye N, Olasode B. Cytopathological review of breast lesions in Ile-Ife Nigeria. The Internet J. of Third World Med. 2008;8:10-25.

Raina V, Bhutani M, Bedi R, Sharma A, Deo SVS, Shukla NK, et al. Clinical features and prognostic factors of early cancer at a major cancer centre in North India. Ind J Cancer. 2005;42:40-5.

Rathi M, Khalid M, Budania SK, Mittal A, Verma N. A clinicopathologic study of various breast lesions with cytohistological correlation. Muller J Med Sci Res. 2015;6:16-22.

Hussain MT. Comparison of fi ne needle aspiration cytology with excision biopsy of breast lump. J Coll Physicians Surg Pak. 2005;15:211-4.

Meena SP, Hemrajani DK, Joshi N. A comparative and evaluative study of cytological and histological grading system profile in malignant neoplasm of the breast – an important prognostic factor. Indian J Pathol Microbiol. 2006;49:199-202.

Kollur SM, El hag IA. FNA of breast fibroadenoma:observer variability and review of cytomorphology with cytohistological correlation. Cytopathol. 2006;17(5):239-44.

Malik R, Bharadwaj VK. Breast lesions in young females a 20 year study for significance of early recognition. Indian J Pathol Microbiol 2003;46(4):55-62.

Carter BA, Page DL, O’Malley FP. Usual epithelial hyperplasia and atypical ductal hyperplasia. Chapter 14. In : O’ malley FP, pinder SE. Breast pathology :a volume in the series foundations in diagnostic pathology. Goldblum JR, editor. Philadelphia: Elsevier. 2006;151-68.

Hashemzadeh SH, Kumar PV, Malekpour N, Hashemi Z, Fattahi F, Malekpour F. Diagnostic accuracy of fine needle aspiration cytology : comparison of results in Tabriz imam Khomeini hospital and shiraz university of medical sciences. IJCP. 2009;3:133-6.

Palombini L, Fulciniti F, Vetrani A, Rosa G, Benedetto G, Zeppa P. Fine needle aspiration biopsies of breast masses a critical analysis of 1956 cases in 8 years (1976-1984). Cancer. 1988:61;2273-7.

Qureshi H, Amanullah A, Khan KM, Deeba F. Efficacy of fine needle aspiration cytology in the diagnosis of breast lumps. JPMI 2007;21(4):301-304.

Pinder SE, Mulligan AM, O’Mally FP. Fibroepithelial lesions including fibroadenoma and phyllodes tumour. Chapter 10. In : O’ malley FP, pinder SE. Breast pathology : a volume in the series foundations in diagnostic pathology. Goldblum JR, editor.Philadelphia : Elsevier. 2006;109-24.

Tiwari M. Role of fine needle aspiration cytology in diagnosis of breast lumps. Kathmandu university medical journal. 2007;5(18):215-7.