To study the correlation between red cell distribution width and left ventricular ejection fraction in patients of acute myocardial infraction

Authors

  • Ramji Sharma Department of Medicine, SMS Medical College, Jaipur, Rajasthan
  • Akram Mohammed Medical Officer, Gangapur City, Rajasthan
  • Mayank Shrivastava Department of Medicine, SMS Medical College, Jaipur, Rajasthan
  • Ajay Mathur Department of Medicine, SMS Medical College, Jaipur, Rajasthan

DOI:

https://doi.org/10.18203/2320-6012.ijrms20161744

Keywords:

Red cell distribution width, Left ventricular ejection fraction, Regional wall motion abnormality

Abstract

Background: Ischemic heart disease (IHD) is a condition in which there is an inadequate supply of blood and oxygen to a portion of myocardium. The objective of study was to assess the correlation between red cell distribution width and left ventricular ejection fraction in patients presenting with acute myocardial infarction.

Methods: Study was conducted on 200 patients admitted at tertiary care centre with acute myocardial infarction satisfying inclusion criteria. Detailed history and clinical examination was done. RDW and other CBC parameters were calculated by an automatic blood counter and measurement of LVEF done by 2D-echocardiography.

Results: Out of 200 patients of acute myocardial infarction 178 (89%) were male and 22 (11%) were female. Both RDW and LVEF are linked in patients of acute myocardial infarctions, as there was statistically significant correlation between high RDW and low LVEF (P <0.01, r - value 0.432).

Conclusions: It is observed that increase RDW and decrease LVEF were linked together which is statistically significant. RDW can be used to assess severity and outcome in patients of acute myocardial infraction on their initial presentation especially at peripheral health centre where echocardiography is not available routinely.

References

Libby P. Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002;105:1135-43.

Isik T, Ayhan E, Kurt M, Tanboga IH, Kaya A, Aksakal E. Is Red Cell Distribution Width a Marker for the presence and Poor Prognosis of Cardiovascular Disease ? EAJM. 2012;44(3):169-71.

Felker GM, Allen LA, Pocock SJ, Shaw LK, McMurray JJ, Pfeffer MA. Red cell distribution width as a novel prognostic maker in heart failure J. Am Coll Cardiol. 2007;50(1):40-7.

Oh J, Kang SM, Hong N, Choi JW, Lee SH, Park S, et al. Relation Between Red Cell Distribution Width with Echocardiographic Parameters in Patients with acute heart failure journal of Cardiac Failure. 2009;15(6):517-22.

Zalawadiya SK, Veeranna V, Panaich SS, Afonso L. 2012 Red cell distribution width and risk of peripheral artery disease : analysis of National Health and Nutrition Examination Survey 1999-2004. Vasc Med 2012;17(3):155-63.

Ani C, Ovbiagele B. Elevated red blood cell distribution width predicts mortality in persons with known stroke. J Neurol Sci 2009;15;277(1-2):103-8.

Zorlu A, Bektasoglu G, Guven FM, Dogan OT, Gucuk E, Ege MR, et al. Usefulness of admission red cell distribution width as a predictor of early mortality in patients with acute pulmonary embolism. Am J Cardiol Epub. 2012;1;109(1):128-34.

Hampole CV, Mehrotra AK, Thenappan T, Gomberg-Maitland M, Shah SJ. Usefulness of red cell distribution width as a prognostic marker in pulmonary hypertension. Am J Cardiology. 2009;15;104(6):868-72.

Macdougall IC, Copper A. The inflammatory response and epoetin sensitivity. Nephrol Dial Transplant. 2002;17 Suppl 1:48-52.

Levine B, Kalman J, Mayer L, Fillit HM, Packer M. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med. 1990;26;323(4):236-41.

Marinkovic D, Zhang X, Yalcin S, Luciano JP, Brugnara C, Huber T et al. Foxo3 is required for the regulation of oxidative stress in erythropoiesis. J Clin Invest 2007;117(8):2133- 44.

Cavusoglu E, Chopra V, Gupta A, Battala VR, Poludasu S, Eng C, et al. Marmur. Relation between red blood cell distribution width (RDW) and all-cause mortality at two years in an unselected population referred for coronary angiography – international Journal of Cardiology. 2010;141(2):141-6.

Dabbah S, Hammerman H, Markiewicz W, Aronson D. Relation Between Red Cell Distribution Width and Clinical Outcomes After Acute Myocardial infraction Am J Cardiology 2010;105:312-7.

Uysal OK, Duran M, Ozkan B, Sahin DY, Tekin K, Elbasan Z, et al. Red cell distribution width is associated with acute myocardial infarction in young patients Cardiology Journal. 2012;19(6):597-602.

Uyarel H, Ergelen M, Cicek G, Kaya MG, Ayhan E, Turkkan C, et al. Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction. Coron Artery Dis. 2011;22(3):138-44.

Downloads

Published

2017-01-02

How to Cite

Sharma, R., Mohammed, A., Shrivastava, M., & Mathur, A. (2017). To study the correlation between red cell distribution width and left ventricular ejection fraction in patients of acute myocardial infraction. International Journal of Research in Medical Sciences, 4(6), 1974–1977. https://doi.org/10.18203/2320-6012.ijrms20161744

Issue

Section

Original Research Articles