Coronavirus 2019: a review of virology, clinical features, diagnosis, and treatment

Authors

  • Shifa Younus Department of Medicine, Nishtar Medical University, Multan, Punjab, Pakistan
  • Hamza Maqsood Department of Medicine, Nishtar Medical University, Multan, Punjab, Pakistan
  • Azouba Gulraiz Department of Medicine, Nishtar Medical University, Multan, Punjab, Pakistan

DOI:

https://doi.org/10.18203/2320-6012.ijrms20203703

Keywords:

Coronavirus, COVID-19, Dyspnoea, Pandemic, Pneumonia

Abstract

Coronavirus 2019 (COVID-19) is an enveloped ribonucleic acid (RNA) virus that is diversely found in humans and wildlife. A total of six species have been identified to cause disease in humans. The most recent outbreak initially presented as pneumonia of unknown etiology in a cluster of patients in Wuhan, China. The epicenter of infection was linked to seafood and exotic animal wholesale markets in the city. SARS-CoV-2 is highly contagious and is a declared global pandemic. This review will introduce a general overview of virology and describe the clinical features, diagnostic testing, and management of COVID-19 patients. There are multiple drug trials going on with some positive results. However, since no vaccine is available, the best way to combat the virus is by preventive methods. Our review will also provide a means to raise awareness among primary and secondary healthcare providers during the current pandemic.

Author Biographies

Shifa Younus, Department of Medicine, Nishtar Medical University, Multan, Punjab, Pakistan

Nishtar Medical University, House physician

Hamza Maqsood, Department of Medicine, Nishtar Medical University, Multan, Punjab, Pakistan

Nishtar Medical University, House physician

References

Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. In Coronaviruses. Humana Press, New York, NY; 2015:1-23.

Centers for Disease Control and Prevention: human coronavirus types, 2020. Available at: https://www.cdc.gov/coronavirus/types.html. Accessed on 22nd April 2020.

Lu H, Stratton C, Tang Y. Outbreak of pneumonia of unknown etiology in Wuhan, China: the mystery and the miracle. J Med Virol. 2020;92:401-2.

Goldsmith C, Tatti K, Ksiazek T. Ultrastructural characterization of SARS coronavirus. Emerg Infect Dis. 2004;10:320-6.

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu, Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet (Lond. Engl.) 2020;395:497-506.

Yu W, Tang G, Zhang L, Corlett RT. Decoding evolution and transmissions of novel pneumonia coronavirus using the whole genomic data. Zoological Res. 2020;41(3):247.

Weiss SR, Leibowitz JL. Coronavirus pathogenesis. Adv Virus Res. 2011;81:85-164.

De Wilde AH, Snijder EJ, Kikkert M, van Hemert MJ. Host Factors in Coronavirus Replication. In Roles of Host Gene and Non-Coding RNA Expression in Virus Infection; Tripp, R.A., Tompkins, S.M., Eds.; Springer International Publishing: Cham, Switzerland; 2018:1-42.

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-33.

Zhou P, Yang XL, Wang XG, Hu B, Zhang L et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270-3.

Lu R, Zhao X, Li, J, Niu P, Yang B, Wu H et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding. Lancet (Lond. Engl.) 2020;395(10224), 565-74.

Wu F, Zhao S, Yu B, Chen YM, Wang W, Hu Y et al. Complete genome characterisation of a novel coronavirus associated with severe human respiratory disease in Wuhan, China. bioRxiv 2020;01(24):919183.

National Microbiology Data Center. Available at: http://nmdc.cn/coronavirus. Accessed on 23rd April 2020.

Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003;426:450-4.

Kakodkar P, Kaka N, Baig MN. A comprehensive literature review on the clinical presentation, and management of the pandemic coronavirus disease 2019 (COVID-19). Cureus. 2020;12(4):e7560.

Li W, Shi Z, Yu M, Ren W, Smith C, Epstein JH et al. Bats are natural reservoirs of SARS-like coronaviruses Science. Science Mag. 2005;310:676-9.

Liu P, Chen W, Chen JP. Viral metagenomics revealed Sendai virus and coronavirus infection of Malayan pangolins (Manis javanica). Viruses. 2019;11:979.

Zhang T, Wu Q, Zhang Z. Probable pangolin origin of SARS-CoV-2 associated with the COVID-19 outbreak. Curr Biol. 2020;30:1-6.

Tang X, Wu C, Li X. On the origin and continuing evolution of SARS-CoV-2. Nat Sci Rev. 2020;36:10.

Sohrabi C, Alsafi Z, O’Neill N. World Health Organization declares global emergency: a review of the 2019 novel coronavirus (COVID-19). Int J Surg. 2020;76:71-6.

Zhang X, Song W, Sun B, Mu J, Dong X, Wang B. Conjunctival polymerase chain reaction-tests of 2019 novel coronavirus in patients in Shenyang, China. medRxiv. 2020.

Ong SWX, Tan YK, Chia PY, Lee TH, Ng OT, Wong MSY et al. Air, surface environmental, and personal protective equipment contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a symptomatic patient. JAMA. 2020;323(16):1610-2.

Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Napoli RD. Features, evaluation and treatment coronavirus (COVID-19). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020.

van Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamsom BN. Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. N Engl J Med. 2020;382(16):1564-7.

Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al. The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: estimation and application. Ann Intern Med. 2020;172(9):577-82.

Julien R, Althaus C. Pattern of early human-to-human transmission of Wuhan. Euro Surveill. 2020,25:2000058.

Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708-20.

Corona virus, 2019. Available at: https://www.cdc.gov/coronavirus/2019 ncov/symptoms-testing/testing.html. Accessed on 28th April 2020.

China Food and Drug Administration. China Food and Drug Administration Emergency Approval of New Coronavirus Nucleic Acid Detection Reagents. Available at: http://www.nmpa.gov.cn/WS04 /CL2056/374264.html. Accessed on 28th April 2020.

Centers for Disease Control and Prevention: persons evaluated for 2019 novel coronavirus-United States, January 2020. Available at: https://www.cdc.gov/mmwr/volumes/69/wr/mm6906e1.htm?s_cid=mm6906e1_x Accessed on 28th April 2020.

Coronavirus disease 2019 (COVID-19). 2020. Available at: https://www.uptodate.com/contents/ coronavirus-disease-2019-covid-19#H2325386707 Accessed on 28th April 2020.

Nankai University News Network. Nankai University Team has Developed a Rapid Antibody Detection Kit for Novel Coronavirus Within 15 Minutes. Available at: http://news.nankai.edu.cn/ywsd/system/2020/02/15/030037569.html.(Accessed on 28th April 2020.

Xiamen University News Network. Xiamen University and Shenzhen Third Hospital successfully developed a novel coronavirus antibody detection kit, which can improve the clinical diagnosis. Available at: http://www.most.gov.cn/dfkj/fj/zxdt/202002 /t20200224_151881.html. Accessed on 28th April 2020.

Salehi S, Abedi A, Balakrishnan S, Gholamrezanezhad A. Coronavirus disease 2019 (COVID-19): a systematic review of imaging findings in 919 patients. Am J Roentgenol. 2020;215:1-7.

Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020;30(3):269-71.

Ai T, Yang Z, Hou H, Zhang C, Chen C, Lv W et al. Correlation of chest CT and RT-PCR testing in Coronavirus Disease 2019 (COVID-19) in China: a report of 1014 cases. Radiol. 2020;29(2):41-5.

Updated IPAC recommendations for use of personal protective equipment for care of individuals with suspect or confirmed COVID-19. 2020. Available at: https://www.publichealthontario.ca//media/documents/ncov/updated-ipac-measures-covid19.pdf?la=en. Accessed on 26th April 2020.

Clinical management of severe acute respiratory infection when COVID-19 is suspected: interim guidance, 2020.

Centers for Disease Control and Prevention: coronavirus disease 2019 (COVID-19) - how to protect yourself. 2020. Available at: https://www.cdc.gov/coronavirus/2019ncov/about/prevention.html. Accessed on 26th April 2020.

Wang D, Hu B, Hu C. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323:1061-9.

Wang Y, Wang Y, Chen Y, Qin Q: Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures. J Med Virol. 2020;10.1002/jmv.25748.

Chen H, Guo J, Wang C. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395:809-15.

National Institutes of Health (NIH). NIH clinical trial of remdesivir to treat COVID-19 begins, 2020. Available at: https://www.nih.gov/news-events/news-releases/nihclinical-trial-remdesivir-treat-covid-19-begins. Accessed on 23rd March 2020.

Zhou D, Dai SM, Tong Q. COVID-19. A recommendation to examine the effect of hydroxychloroquine in preventing infection and progression. J Antimicrob Chemother. 2020;83(1):77-9.

Xu X, Han M, Li T. Effective treatment of severe COVID-19 patients with tocilizumab. Chin Xiv. 2020;117(20):10970-5.

Wang M, Cao R, Zhang L. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020;30:269-71.

Fang L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respir Med. 2020;8(4):e21.

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Published

2020-08-26

How to Cite

Younus, S., Maqsood, H., & Gulraiz, A. (2020). Coronavirus 2019: a review of virology, clinical features, diagnosis, and treatment. International Journal of Research in Medical Sciences, 8(9), 3401–3408. https://doi.org/10.18203/2320-6012.ijrms20203703

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Section

Review Articles