Incidence, characteristics, pattern and management of ovarian cancer in Abuja, Nigeria
DOI:
https://doi.org/10.18203/2320-6012.ijrms20203665Keywords:
Abuja, Cancer, Histological, Outcome, Ovarian, PatternAbstract
Background: The prevalence of ovarian cancer is thought to be increasing with huge burden of the disease with no comprehensive cancer center that can offer appropriate care in developing countries. However, little is known about the incidence, pattern and outcome of this disease in Abuja, Nigeria. Therefore, the aim of this study was to review the pattern of care offered to patients with ovarian cancer in our center and to evaluate patients’ outcome.
Methods: This was a retrospective review of all the patients with histologically confirmed ovarian cancers admitted to the gynecological ward of the hospital over a period of 5 years. Relevant information was extracted from the ward register and patients medical case records. Data were analyzed using statistical package for social science version 23 and results were then presented in tables and chart.
Results: Ovarian cancers constituted 19.6% and 5.6% of all gynecological cancers and all gynecological admissions respectively. The mean age at presentation was 50.2±8.5 years and premenopausal 32 (55%) constituting the majority. A large proportion 43 (74.1%) of the patients were parous. The commonest symptoms at presentation were abdominal swelling (86.2%), and abdominal pain (53.4%) with the majority 38 (65.5%) presenting in an advanced stage. The commonest histological type of ovarian cancers was epithelial accounting for 30 (51.7%) of all ovarian cancers. Common treatment modality was surgery and chemotherapy and majority 32 (55.3%) of the patients had cytoreductive surgery with 19 of them having optimum cytoreduction and 33 (57%) benefitted from chemotherapy. Lost to follow- up was significantly high (55%) and mortality rate was 15.5%.
Conclusion: Cases of ovarian cancers are on the increase. Women presented at an advanced stage of the disease, which resulted in short survival times. Failure of optimal management was also worsened by poor compliance to treatment with high patients' default rate.
References
Umar U A, Yakasai IA, Adamou N. Ovarian cancer: Pattern of care in a tertiary health centre in sub-saharan Africa. Trop J Obstet Gynaecol. 2016;33:288-91.
Ferlay J, Soerjomataram I, Dikshit R. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359-E.
Singh D, Kapok A, Jakhar, SL, Bagri PK. Kumar HS. Multiple metastases from ovarian cancer; S Afr J OG. 2014;20(3):94-5.
Okunade KS, Okunola H, Okunowo AA, Anorlu RI. A five-year review of ovarian cancer at a tertiary institution in Lagos, South-West, Nigeria. Niger J Gen Pract. 2016;14:23-7.
Mathur M, Mishra A, Agarwal A, Amit S. Clinico-pathological analysis of ovarian tumors: A retrospective study. Int J Clin Obstet Gynaecol. 2018;2(5):29-31.
Zayyan MS, Ahmed SA, Oguntayo AO, Kolawole AO, Olasinde TA. Epidemiology of ovarian cancers in Zaria, Northern Nigeria: a 10-year study. Int J Womens Health. 2017;9:855-60.
Katumba J, Obore S, Kaye DK. Health-related quality of life among patients with ovarian cancer at Mulago Hospital, Uganda. Int J Gynaecol Obstet. 2013;122:115-7.
Odukogbe AA, Adebamowo CA, Ola B, Olayemi O, Oladokun A, Adewole IF, et al. Ovarian cancer in Ibadan: characteristics and management. J Obstet Gynaecol. 2004;24(3):294-7.
Berrino F, De Angelis R, Sant M. Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995-99: results of the EUROCARE-4 study [published correction appears in Lancet Oncol. 2007;8(10):868. Lasota, Magdalena B [corrected to Bielska-Lasota, Magdalena]. Lancet Oncol. 2007;8(9):773-83.
Momemnimovahed Z, Tizmobalk A, Taheri S, Salehiniya H. Ovarian cancer in the world: epidemiology and risk factors. Int J Womens Health. 2019;11:287-99.
Gao Y, Li Y, Zhang C. Evaluating the benefits of neoadjuvant chemotherapy for advanced epithelial ovarian cancer: a retrospective study. J Ovarian. 2019;12:85.
Abuidris DO, Weng H, Elhaj AM, Eltayeb EA, Elsanousi M, Ibnoof RS, et al. Incidence and survival rates of ovarian cancer in low-income women in Sudan. Mol Clin Oncol. 2016;5(6):823-28.
Iyoke CA, Ifeadike CO, Nnebue CC, Nkwo PO, Ezugwu EC, Edosuyi L, et al. A ten-year review of ovarian cancer in Enugu, South East Nigeria Discussion. Afrimedic J. 2011;2(1):8-12.
Joseph A, Olisaemeka EP, Chukwudi OR, Igwe NM, Rose AM, Conrad EC. Frequency and pattern of gynecological cancers in federal teaching hospital, Abakaliki, Nigeria. J Basic Clin Reprod Sci. 2015;4:54-7.
Iyorke CA, Ugwu GO, Ezugwu EC, Ezugwu FO, Lawani LO, Onyebuchi AK. Challenges associated with gynaecological cancers in a tertiary hospital in South East Nigeria. Int J Womens Health. 2014;6:123-30.
Gilani MM, Behnamfar F, Zamani F, Zamani N. Frequency of different types of ovarian cancer in Vali-e-Asr Hospital (Tehran University of Medical Sciences). Pak J Biol Sci. 2007;10:3026-8.
Abuidri DO, Weng HY, Elgaylani, ltayeb AE, Mohamed Elsanousi M, Ibnoof et al. lncidence and survival rates of ovarian cancer in low-income women in SudanMol Clin Oncol. 2016;5(6):823-28.
Wong KH, Mang OW, Au KH, Law SC. Incidence, mortality, and survival trends of ovarian cancer in Hong Kong, 1997 to 2006: A population-based study. Hong Kong Med J. 2012;18:466-74.
Singh D, Kapoor A, Jakhar SL, Bagri PK, Kumar HS. Multiple metastases from ovarian cancer. S Afr J OG. 2014;20(3):94-5.
Buhari MO, Ojo BA, Ijaiya MA, Aboyeji PA. Ovarian cancers in Ilorin, Nigeria - a review of over 80 cases. Nig Q J Hosp Med. 2005;15:127-30.
Gharoro EP, Eirewele O. Cancer of the ovary at the University of Benin Teaching Hospital: a 10-year review, 1992-2001. Afr J Med Sci. 2006;35:143-7.
Murad A. Ovulation induction and ovarian tumor: the debate continues. J Pak Med Assoc. 1998;48:353-6.
Al Rawahi T, Lopes AD, Bristow RE. Surgical cytoreduction for recurrent epithelial ovarian cancer. Cochrane Database Syst Rev. 2013;2013(2):CD008765.
Bristow RE, Montz FJ, Lagasse LD. Survival impact of surgical cytoreduction in stage IV epithelial ovarian cancer. Gynecol Oncol. 1999;72:278-87.
The Recognition and Initial Management of Ovarian Cancer, National Collaborating Centre for Cancer Cardiff (UK): 2011 NICE Clinical Guidelines, No. 122. Available at: https://www.nice.org.uk/guidance/cg122. Accessed on 2nd June 2020.
Iyoke CA, Ugwu GO, Ezugwu EC, Onah N, Ugwu O, Okafor O. Incidence, pattern and management of ovarian cancer at a tertiary medical center in Enugu, South East Nigeria. Ann Med Health Sci Res. 2013;3:417-21.
Chan JK, Urban R, Cheung MK, Osann K, Shin JY, Husain A, et al. Ovarian cancer in younger vs older women: a population-based analysis. Br J Cancer. 2006;95:1314-20.
O'Malley CD, Cress RD, Campleman SL, Leiserowitz GS. Survival of Californian women with epithelial ovarian cancer, 1994-1996: a population-based study. Gynecol Oncol. 2003;91:608-15.
Tingulstad S, Skjeldestad FE, Halvorsen TB, Hagen B. Survival and prognostic factors in patients with ovarian cancer. Obstet Gynecol. 2003;101:885-91.
