Determination of nitrofurantoin and fosfomycin susceptibility among urinary Escherichia coli isolates

Rachana Kanaujia; Amit Kumar; Malay Bajpai

doi:10.18203/2320-6012.ijrms20203676

Authors

Rachana Kanaujia Department of Microbiology, Homi Bhabha Cancer Hospital, Varanasi, Uttar Pradesh, India
Amit Kumar Department of Microbiology, Rama Medical College Hospital and Research Centre, Hapur, Uttar Pradesh, India
Malay Bajpai Department of Pathology, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20203676

Keywords:

Urinary tract infections, E. coli, Nitrofurantoin, Fosfomycin

Abstract

Background: Urinary tract infections (UTIs) are one of the most common infections. For treatment of UTIs, there are limited antibiotics due to increased resistance among uropathogens. Two older antibiotics; Nitrofurantoin and Fosfomycin have become novel oral therapeutic options against uropathogens. Aim of the study was to identify UTI causing micro-organisms and evaluate in-vitro activity of nitrofurantoin and fosfomycin against most common isolated organism (E. coli).

Methods: Results of urine samples culture and susceptibility testing over a period of 1 year were analysed and included in this study.

Results: Micro-organisms were isolated from 568 urine samples. Most commonly isolated organism was Escherichia coli (40.50%), followed by Klebsiella spp. (20.07%) and Staphylococcus spp. (17.07%). Susceptibility of E. coli to nitrofurantoin and fosfomycin was 91.74% and 65.65% respectively.

Conclusion: Good activity of nitrofurantoin and fosfomycin against E. coli indicates that these two drugs are potential therapeutic alternatives for urinary tract infections.

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