A comparative study of coronary artery disease in diabetics and non-diabetics


  • Prabhat Pandey Department of Medicine, CM Medical College, Durg, Chhattisgarh
  • Rajendra Kumar Chandrakar Department of Pathology, CM Medical College, Durg, Chhattisgarh
  • Prashant Dobariya Department of Medicine, CM Medical College, Durg, Chhattisgarh
  • Pavan Kumar Namewar Department of Medicine, CM Medical College, Durg, Chhattisgarh
  • Pooja Pandey Department of Dermatology, AIIMS, Raipur, Chhattisgarh




Coronary artery disease, Diabetes, Non-diabetics


Background: Cardiovascular diseases accounts for the greatest burden of morbidity and mortality worldwide, both in developed and in developing countries. Coronary Heart Disease  makes up more than half of all CVD deaths in men and women  under 75 years of age, is eases with a lifetime risk of developing CHD after  age 40 years, of 49 per cent for men and 32 per cent for women. The Framingham study showed that the risk of cardiovascular death was increased 4-5 fold in women and 2 fold in men with predominantly type-2 diabetes mellitus.

Methods: The present study was undertaken at Chandulal Chandrakar Memorial Hospital, Bhilai, Dist. Durg, Chhattisgarh, India between the periods of September- 2010, September-2012 (2 years). 120 cases of CAD were studied, out of which 60 cases are diabetic CAD and 60 cases are non-diabetic CAD. Sample is drawn by simple random technique. Ethical approval was obtained from institutional ethical committee. Total Cases were 120, Diabetic CAD (Group -1)-60 and Non-diabetic CAD (Group 2)-60. 

Results: Male to female ratio in group-1 was 2.3:1 and in group-2 it was 1.7:1. Females were commonly affected in the diabetic group than non-diabetic group. Diabetics are more obese than non-diabetics. Non-diabetics have higher ideal body weight 58.33% than diabetic (36.66%) (p<0.001); whereas proportion of over-weight people was same in both groups. Among the diabetic group and non-diabetic group maximum number of cases belonged to low risk category with total cholesterol, triglycerides and LDL cholesterol, but with borderline risk with HDL cholesterol.

Conclusions: CAD in diabetics had considerably higher percent of severe and unpredictable presentation. Diabetics have a higher risk factor profile and poor clinical outcome.



Mendis S, Puska P, Norrving B. (eds.). Global Atlas on Cardiovascular Disease Prevention and Control. Geneva: World Health Organization. 2011.

Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, et al. American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics—2013 update: a report from the American Heart Association. Circulation. 2013;127, e6–e245.

Harrisons Principles Of Internal Medicine 17th Edition New Delhi, Mcgraw- Hill, Fauci, Braunwald, Kasper, Hauser, Longo, Jameson, Loscalzo. 2008;338:2275-7.

Ramachandran A, Vishwanathan M, Mohan V. Epidemiology of NIDDM in Indians. JAPI. 1993;Suppl 1:1-4.

Nathan DM, Meigs J, Singer DE. The Epidemiology of cardiovascular disease in Type 2 diabetesmellitus: How sweat it is/or is it. The Lancet 1997;350(s1):s14-8.

Abbott RD, Donahue RP, Kannel WB, Wilson PW. The Impact of Diabetes on Survival Following Myocardial Infaction in Mens Vs women. The Framingham Study. AMA. 1988;260(23):3456-60.

Kannel WB, Abbott RD. Incidence and Prognosis of Unrecongnised Myocardial Infarction: An Update on the Framingham study. N.Engl. J. Med. 1984;311:1144-7.

http://www.ndei.org/ uploadedFiles/ Common/ NDEI/ Treatment_Guidelines/ ADA%202015%20Summary%20PDF.pdf

https://www.nhlbi.nih.gov/ files/docs/ guidelines/ express.pdf

Mak KH, Moliterno DJ, Granger CB, Miller DP, White HD, Wilcox RG, et al. Influence of Diabetes Mellitus on Clinical Outcome in the thrombolytic era of Acute Myocardial Infarction-GUSTO-1 Investigations. J. Am. Coll. Cardiol. 1997;30:171-9.

Viberti GC, Messent J. Risk Factors For Renal and Cardiovascular Disease in Diabetic Patients” Cardiology. 1991;79 (suppl 1):55-61.

Turner RC, Millns H, Neil HA, Stratton IM, Manley SE, Matthews DR, et al. Risk Factors for Coronary Artery Disease in Non-insulin Dependent diabetes Mellitus: United Kingdom Prospective Diabetes Study (UKPDS:23). BMJ. 1998;316:823-8.

Laakso M, Lehto S, Penttilä I, Pyörälä K. Lipids and Lipoproteins Predicting Coronary Heart Disease Mortality and Morbidity in Patients with NIDDM” Circulation. 1993;88(4 Pt 1):1421-30.

Ramachandran A. Increase in the Prevalence of NIDDM and Evidence of High Cardiovascular Risk in Urban South Indian Popultion. 15th International Diabetes Fed. Congress, Kobe, Japan. 1994;171.

Singh RB, Niaz MA. Coronary Risk Factors in Indians. The Lancet. 1995;346:778-2.

Eng C, Shantha CE, Bee Yian. Prevalence of Diabetes and Ethnic Differences in Cardiovascular Risk Factors:The 1992, Singapore National Health Survey. Diabetes care. 1999;22:241-7.

McKeigue PM, Shah B, Marmot MG. Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians. The Lancet. 1991;337(8738):382-6.

Seibaek M, Sloth C, Vallebo L, Hansen T, Urhammer SA, Burchardt H, et al. Glucose Tolerance Status and Severity of Coronary Artery Disease in Men Referred to Coronary Arteriography. Am. Hert. J. 1997;133:622-9.

Kouvaras. G., Cokkinos D, Spyropoulou M. Increased Mortality of Diabetes after Myocardial Infarction Attributed to Diffusely Impaired Left V entricular Performance as Assessed by Echocardiography. Jph. Heart. J. 1988;29(1);1-9.

Stone PH, Muller JE, Hartwell T, York BJ, Rutherford JD, Parker CB. et al. The Effect of Diabetes Mellitus on Prognosis and Serial Left Ventricular Function after Myocardial Infarction: Contribution of Both Coronary Artery Disease and Siastolic Left Ventricular Dysfunction to Adverse Prognosis – The MILIS Study Group” J.Am.Coll. Cardiol. 1989;14(1):49-57.

Henry P, Makowski S, Richard P. Increased Incidence of Moderate Stenosis among Patients with Diabetes: Substrate for Myocardial Infarction? Am. Hert. J. 1997;134:1037-43.




How to Cite

Pandey, P., Chandrakar, R. K., Dobariya, P., Namewar, P. K., & Pandey, P. (2017). A comparative study of coronary artery disease in diabetics and non-diabetics. International Journal of Research in Medical Sciences, 4(6), 2252–2258. https://doi.org/10.18203/2320-6012.ijrms20161795



Original Research Articles