Published: 2017-01-02

Oral premedication for pediatric anaesthesia: a comparison between midazolam and clonidine

Anupam Das, Kishore Das, Minoti Baruah, Manigreeva Krishnatreya, Amal Chandra Kataki


Background:In children any anticipated surgery is associated with profound psychological stress to the patients. To allay this stress and anxiety, wide variety of pharmacological interventions are used.

Methods: A prospective observational study was carried out between July’2005 and June’2006 in a tertiary care hospital in Assam. The study included children undergoing surgery under general anaesthesia in age group 2-10 years. Sixty children were divided into two groups, in one group patients received oral midazolam and other group received oral clonidine as pre-medicant.

Results: In the midazolam group 23 (76.67%) children had no apprehension after parental separation and at induction (P˂0.001), sedation score at induction was significant higher in midazolam group versus clonidine group (93.33% versus 66.6%, P<0.01), clonidine resulted in a more stable pulse and blood pressure peri-operatively (P<0.05).

Conclusion: Oral midazolam has better efficacy in terms of preoperative sedation and oral clonidine had stable hemodynamic profile and better analgesia in the clonidine group.


Clonidine, Midazolam, Pediatric, Pre-medications

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